CAS 3380-34-5 MFCD00800992-5-Chloro-2-(2,4-dichlorophenoxy)phenol 5-氯-2-(2,4-二氯苯氧基)苯酚 TAO{mole}

5-Chloro-2-(2,4-dichlorophenoxy)phenol 5-氯-2-(2,4-二氯苯氧基)苯酚

CAS 3380-34-5 MFCD00800992

化学结构图

SMILES: Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl

化学属性

Mol. Formula	C12H7Cl3O2
Mol. Weight	289.54
Melting Point	56-60°C
TSCA	Yes
Density	1.49
Appearance	无色长针状结晶。熔点54-57.3℃（60-61℃）。微溶于水，溶于乙醇、丙酮、乙醚和碱溶液。有氯苯酚气味。
Boiling Point	344.6°C at 760 mmHg

别名和识别编码

Chemical Name	5-Chloro-2-(2,4-dichlorophenoxy)phenol
CAS Number	3380-34-5
Alfabeta Name	CHLORODICHLOROPHENOXYPHENOL 5224()----,
MDL Number	MFCD00800992
Synonym	Triclosan {LY} Triclosan {} {LY} Triclosan {} {} {LY} Triclosan {} {} {} {LY} Triclosan {} {} {} {} {LY} Triclosan {} {} {} {} {} {LY} Triclosan {} {} {} {} {} {} {LY} Triclosan {} {} {} {} {} {} {} {LY} Triclosan {} {} {} {} {} {} {} {} {LY} Triclosan {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} Triclosan {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} Triclosan {} {} {} {} {} {} {} {} {} {} {} {LY} Triclosan {} {} {} {} {} {} {} {} {} {} {} {} {LY} Triclosan {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Triclosan {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Triclosan {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Triclosan {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Triclosan {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Triclosan {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID	87577595
EC Number	222-182-2
Reaxys-RN	2057142
Merck Number	9657
Beilstein Registry Number	2057142
Chemical Name Translation	5-氯-2-(2,4-二氯苯氧基)苯酚
Wiswesser Line Notation	QR CG FOR BG DG
LabNetwork Molecule ID	LN00175880
InChI	InChI=1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H
Canonical SMILES	OC1=CC(Cl)=CC=C1OC2=CC=C(Cl)C=C2Cl

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品牌质保精细包装现货库存一流品牌服务

产品应用

三氯生(Irgasan)是一种广谱抗菌剂，它抑制细菌和疟原虫中II型脂肪酸合成酶(FAS-II)，也抑制哺乳动物脂肪酸合成酶(FASN), 而且可能还具有抗癌活性。

安全信息

Warnings IRRITANT

WGK Germany3

GHS Symbol

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P302+P350
P305+P351+P338
P305+P351+P338+P337+P313
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P332+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
H319 Causes serious eye irritation 严重刺激眼睛
H303 May be harmfully swallowed 吞食可能有害

Hazard Codes 9

RTECSKO1100000

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Signal word Warning

UN Number 3077 UN 3077 9/PG 3 UN3077

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S46 If swallowed, seek medical advice immediately and show this container or label 食入时，立即求医并出示容器/标签；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S39 Wear eye/face protection 戴眼睛/面孔保护装置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
R50/53

Packing GroupIII

Hazard Class9

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 28,985,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 84 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 28,985,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 89 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 28,985,1977

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TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4530 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   26UZAB "Pesticides Symposia; Collection of Papers Presented at the Sixth &
   Seventh Inter-American Conferences on Toxicology and Occupational Medicine,
   Miami, FL," Miami, FL, J.L. Halos, 1968-70  Volume(issue)/page/year:
   6,245,1968/1

TYPE OF TEST            : LD50

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 5 mg/disc
REFERENCE :
   JOSCDQ Journal of SCCJ (Society of Cosmetic Chemists of Japan).  (Nippon
   Keshohin Gijutsushakai, c/o Shiseido, 7-5-5 Ginza, Chuo-ku, Tokyo 104,
   Japan)  V.10-    1976-  Volume(issue)/page/year: 15,243,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4400 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   ESKHA5 Eisei Shikenjo Hokoku.  Bulletin of the Institute of Hygienic
   Sciences.  (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
   Setagaya-ku, Tokyo 158, Japan)  V.1-    1886-  Volume(issue)/page/year:
   (105),28,1987

Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

消毒剂:三氯生是一种外用高效广谱抗菌消毒剂，又称为二氯苯氧氯酚、三氯新、克力恩、抑菌纯、卫洁纯、洁美新、三氯沙，常态为白色或灰白色晶状粉末，稍有酚臭味。不溶于水，易溶于碱液和有机溶剂。化学性质稳定、耐温、耐酸碱水解，不发生任何毒性表症和环境污染，是国际上公认的特效杀菌剂品种。它可以杀灭金黄色葡萄球菌、大肠杆菌等细菌及白色念珠菌等真菌，对病毒（如乙型肝炎病毒等）也有抑止作用,同时能够保护有益细菌。三氯生的杀菌机理是先吸附于细菌细胞壁上，进而穿透细胞壁，与细胞质中的脂质、蛋白质反应，导致蛋白质变性，进而杀死细菌。目前已经被广泛应用于高效药皂(卫生香皂、卫生洗液)、除腋臭(脚气雾剂)、消毒洗手液、伤口消毒喷雾剂、医疗器械消毒剂、卫生洗面奶(膏)、空气清新剂及冰箱除臭剂等日用化学品中，也用于卫生织物的整理和塑料的防腐处理，高纯度的可用于治疗牙龈炎、牙周炎及口腔溃疡等的疗效牙膏及漱口水中。国家规定含量不得超过0.3%。
用途三:三氯生(Irgasan)是一种广谱抗菌剂，它抑制细菌和疟原虫中II型脂肪酸合成酶(FAS-II)，也抑制哺乳动物脂肪酸合成酶(FASN), 而且可能还具有抗癌活性。
致癌性:2004年美国弗吉尼亚理工大学一位老师（Dr. Peter Vikesland）在实验中发现，含有三氯生的产品与含氯的自来水发生反应后，可形成一种被称为“哥罗芳”的物质，也就是氯仿，化学名为三氯甲烷，是一种无色、易挥发、具特殊甜味的液体，遇光会氧化生成氯化氢和光气。曾被用作麻醉剂。动物试验发现，这种物质会对心脏和肝脏造成损伤，具有轻度致畸性，可诱导小白鼠发生肝癌，但至今尚无人体致癌的研究资料。为保险起见，国际癌症研究中心和美国都将氯仿列为对人体有潜在威胁的可疑致癌物。
用途一:用于高档日化产品的生产，医疗、饮食行业器械消毒剂、织物抗菌防臭整理剂的配制等
三氯生价格(试剂级):更新日期产品编号产品名称包装价格 2011/04/16 T1872 2,4,4'-三氯-2'-羟基二苯醚 2,4,4'-Trichloro-2'-hydroxydiphenyl Ether 500G 4290元 2011/04/16 T1872 2,4,4'-三氯-2'-羟基二苯醚 2,4,4'-Trichloro-2'-hydroxydiphenyl Ether 25G 480元 2010/05/25 L18655 5-氯-2-(2,4-二氯苯氧基)苯酚,99% 5-Chloro-2-(2,4-dichlorophenoxy)phenol, 99% 10g 230元
TCI Shanghai:2,4,4'-三氯-2'-羟基二苯醚 2,4,4'-Trichloro-2'-hydroxydiphenyl Ether,>;96.0%(GC)(3380-34-5)
Sigma Aldrich:3380-34-5(sigmaaldrich)
Alfa Aesar:5-氯-2-(2,4-二氯苯氧基)苯酚,99% 5-Chloro-2-(2,4-dichlorophenoxy)phenol, 99%(3380-34-5)
用途二:防腐剂和防霉剂，用于化妆品，乳剂和树脂，也用来制造消毒药皂。该品小鼠口服LD50为4g/kg。
三氯生价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 T1872 2,4,4'-三氯-2'-羟基二苯醚 2,4,4'-Trichloro-2'-hydroxydiphenyl Ether 500G 4070元 2014/06/02 T1872 2,4,4'-三氯-2'-羟基二苯醚 2,4,4'-Tr
牙膏标准:我国使用的牙膏国标是从2009年2月1日开始实行的牙膏新国家标准(GB8372-2008)。与2001年版的牙膏标准相比，新国标在许多方面都做了增加和调整。新牙膏国标中，禁止添加或严格限制的成分有近1500种，包括二甘醇、三氯生等。对二甘醇的规定是不许人为在原料中添加，如作为杂质带入，在牙膏中的含量不得超过0.1%。三氯生则被列入到允许添加的防腐剂中，但明确不得超过0.3%。新国标将成人含氟牙膏的氟含量规定为0.04%-0.15%，并规定儿童含氟牙膏中氟含量应在0.05%到0.11%之间。
图谱信息:三氯生(3380-34-5)质谱(MS)