7-Chloro-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxoquinoline-3-Carboxylic Acid 7-氯-6-氟-1-环丙基-1,4-二氢-4-氧-3-喹啉羧酸

CAS 86393-33-1 MFCD00792458

化学结构图

86393-33-1
SMILES: OC(=O)C1=CN(C2CC2)C2C=C(Cl)C(F)=CC=2C1=O

化学属性

Mol. FormulaC13H9ClFNO3
Mol. Weight282
Melting Point242-245

别名和识别编码

Chemical Name7-Chloro-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxoquinoline-3-Carboxylic Acid
CAS Number86393-33-1
Alfabeta NameCHLOROCYCLOPROPYLFLUOROOXODIHYDROQUINOLINECARBOXYLICACID 7164143-----------,
MDL NumberMFCD00792458
Synonym 7-氯-6-氟-1-环丙基-1,4-二氢-4-氧-3-喹啉羧酸 Fluoroquinolonic Acid Fluoroquinolonic acid
EC Number405-050-0
Reaxys-RN4515704
PubChem Substance ID87560826
Chemical Name Translation7-氯-6-氟-1-环丙基-1,4-二氢-4-氧-3-喹啉羧酸
LabNetwork Molecule IDLN00158192
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分类

  • {SA} Analytical Standards, Analytical/Chromatography, Chromatography, Ciprofloxacin Hydrochloride Impurities, Pharmaceutical Impurities, Pharmaceutical Secondary Standards, Pharmaceutical Standards
  • {SNA} Building Blocks, C11 to C30, Chemical Synthesis, Fluorinated Building Blocks, Halogenated Heterocycles, Heterocyclic Building Blocks, Heterocyclic Fluorinated Building B
  • {SNA} Building Blocks, C11 to C30, Chemical Synthesis, Fluorinated Building Blocks, Halogenated Heterocycles, Heterocyclic Building Blocks, Heterocyclic Fluorinated Building Blocks, Other Fluorinated Heterocycles, Quinolines
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities

产品应用

  • A metabolite of Ciprofloxacin, a fluorinated quinolone antibacterial.

相关文献及参考

  • Siefert, H.M., et al.: Arzneim.-Forsch., 36, 1496 (1986),
  • Zhi, C., J. Med. Chem., 49, 1455 (2006),
  • Trefi, S., et al.: J. Pharm. Biomed. Anal., 44, 743 (2007),

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany2
Precautionary statements
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P312+P330
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
RTECSVB1993795
Hazard Codes Xn
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >677 mg/m3/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 15(Suppl 1),S96,1996

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 583 mg/kg
TOXIC EFFECTS :
   Skin and Appendages - hair
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 15(Suppl 1),S96,1996

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 15(Suppl 1),S96,1996

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Quinolines - Halogenated Heterocycles
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Impurities - Pharmaceutical Standards
  6. Ciprofloxacin Hydrochloride Impurities - Pharmaceutical Impurities
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Cyclopropy 环丙基化合物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Cyclopropy 环丙基化合物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Cyclopropy 环丙基化合物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Cyclopropy 环丙基化合物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Cyclopropy 环丙基化合物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Cyclopropy 环丙基化合物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Cyclopropy 环丙基化合物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Cyclopropy 环丙基化合物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Cyclopropy 环丙基化合物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Cyclopropy 环丙基化合物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Cyclopropy 环丙基化合物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Cyclopropy 环丙基化合物

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