Estrone 3-O-Sulfamate
CAS 148672-09-7 MFCD00676965
化学结构图
SMILES: C[C@@]12CC[C@@H]3[C@H](CCC4=CC(=CC=C43)OS(N)(=O)=O)[C@H]1CCC2=O |&1:1,4,5,19|
化学属性
| Mol. Weight | 349.44 |
|---|---|
| Mol. Formula | C18H23NO4S |
别名和识别编码
| CAS Number | 148672-09-7 |
|---|---|
| Chemical Name | Estrone sulfamate |
| Synonym | 1,3,5(10)-Estratrien-17-one 3-sulfamate 3-[(Aminosulfonyl)oxy]estra-1,3,5(10)-trien-17-one EMATE Estrone 3-Sulfamate Estrone O-Sulfamate Estrone Sulfamate |
| MDL Number | MFCD00676965 |
| Chemical Name Translation |
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资金保障
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分类
- Biochemicals and Reagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Estrone sulfatase
- {SNA} Biochemicals and Reagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Estrone sulfatase
- {SNA} D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Estrone sulfatase, 生化试剂, 酶、抑制剂和底物
产品应用
- A potent inhibitor of estrone sulfatase. Inhibits estrone sulfatase >99% at 0.1uM in intact MCF-7 cells, IC50=65pM.
相关文献及参考
- Woo, L.W., et al.: J. Med. Chem., 41, 1068 (1998)
- 1. Nussbaumer, P., et al., 2-Substituted 4-(thio)chromenone 6-O-sulfamates: potent inhibitors of human steroid sulfatase J. Med. Chem. 45 , 4310-4320, (2002)
- Purohit, A., et al. Biochemistry 34 , 11508, (1995) 摘要
- Woo, L.W.L., et al. J. Med. Chem. 39 , 1349, (1996) 摘要
