MG 132 MG132,蛋白酶体抑制剂
CAS 133407-82-6 MFCD00674886
化学结构图
SMILES: CC(C)C[C@@H](NC(=O)OCC1C=CC=CC=1)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(C)C)C=O |&1:4,19,27|
化学属性
| Mol. Formula | C26H41N3O5 |
|---|---|
| Mol. Weight | 476 |
| TSCA | No |
| Density | 1.073 |
| Boiling Point | 682 |
别名和识别编码
| Chemical Name | MG 132 |
|---|---|
| Synonym | MG-132 Z-Leu-Leu-Leu-al Z-Leu-Leu-Leu-aldehyde |
| MDL Number | MFCD00674886 |
| PubChem Substance ID | 24892475 |
| CAS Number | 133407-82-6 |
| Chemical Name Translation | MG132,蛋白酶体抑制剂 |
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分类
- {SNA} Aldehydes, Application Index, Building Blocks, C13-C60, Calpain and Proteasome Inhibitors, Carbonyl Compounds, Cell Signaling Enzymes, Chemical Synthesis, Inhibitors, Organic Building Blocks, Proteasome, Calpain and Lysosomal Proteases, Proteasomes,
相关文献及参考
- [2]. Fan WH, et al. Proteasome inhibitor MG-132 induces C6 glioma cell apoptosis via oxidative stress. Acta Pharmacol Sin. 2011 May;32(5):619-25.
- [3]. Tsubuki S, et al. Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine. J Biochem. 1996 Mar;119(3):572-6.
- [4]. Fiedler MA, et al. Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132. Am J Respir Cell Mol Biol. 1998 Aug;19(2):259-68.
- [5]. MacLaren AP, et al. p53-dependent apoptosis induced by proteasome inhibition in mammary epithelial cells. Cell Death Differ. 2001 Mar;8(3):210-8.
- [6]. Han YH, et al. The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH. Oncol Rep. 2009 Jul;22(1):215-21.
- [7]. Dang L, et al. Proteasome inhibitor MG132 inhibits the proliferation and promotes the cisplatin-indu
安全信息
GHS Symbol
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
