N-(Benzo[d][1,3]dioxol-5-ylmethyl)-6-chloroquinazolin-4-amine N-(苯并[d][1,3]二氧戊环-5-基甲基)-6-氯喹唑啉-4-胺
CAS 150450-53-6 MFCD00673946
化学结构图
SMILES: ClC1=CC2=C(NCC3C=C4OCOC4=CC=3)N=CN=C2C=C1
化学属性
| Mol. Formula | C16H12ClN3O2 |
|---|---|
| Mol. Weight | 313.74 |
别名和识别编码
| Chemical Name | N-(Benzo[d][1,3]dioxol-5-ylmethyl)-6-chloroquinazolin-4-amine |
|---|---|
| Synonym | 4-((3,4-Methylenedioxybenzyl)amino)-6-chloroquinazoline MBCQ |
| MDL Number | MFCD00673946 |
| PubChem Substance ID | 329824721 |
| Chemical Name Translation | N-(苯并[d][1,3]二氧戊环-5-基甲基)-6-氯喹唑啉-4-胺 |
| CAS Number | 150450-53-6 |
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分类
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, New Products, Phosphodiesterase Inhibitors
- {SNA} Bioactive Small Molecule Alphabetical Index, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, M, Phosphodiesterase Inhibitors, 生物活性小
相关文献及参考
- [2]. Jeffery D MacPherson, et al. Inhibition of phosphodiesterase 5 selectively reverses nitrate tolerance in the venous circulation J Pharmacol Exp Ther. 2006 Apr;317(1):188-95.
- [3]. Takeharu Kaneda, et al. Lack of cyclic nucleotide regulation of MBCQ-induced relaxation of rat ileal smooth muscle. J Smooth Muscle Res. 2003 Jun;39(3):47-54.
- [1]. Y Takase, et al. Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity. J Med Chem. 1994 Jun 24;37(13):2106-11.
- [1]. Y Takase, et al. Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity. J Med Chem. 1994 Jun 24;37(13):2106-11.
- [2]. Jeffery D MacPherson, et al. Inhibition of phosphodiesterase 5 selectively reverses nitrate tolerance in the venous circulation J Pharmacol Exp Ther. 2006 Apr;317(1):188-95.
- [3]. Take
