4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-methoxyphenyl)methyl)-N,N-diethylbenzamide 4-((R)-((2S,5R)-4-烯丙基-2,5-二甲基哌嗪-1-基)(3-甲氧基苯基)甲基)-N,N-二乙基苯甲酰胺
CAS 156727-74-1 MFCD00672673
化学结构图
SMILES: C[C@H]1CN(CC=C)[C@H](C)CN1[C@@H](C1=CC(=CC=C1)OC)C1C=CC(=CC=1)C(=O)N(CC)CC
化学属性
| Mol. Formula | C28H39N3O2 |
|---|---|
| Mol. Weight | 449.63 |
别名和识别编码
| Chemical Name | 4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-methoxyphenyl)methyl)-N,N-diethylbenzamide |
|---|---|
| CAS Number | 156727-74-1 |
| Synonym | (+)-4-[(?R)-?-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide SNC 80 SNC-80 SNC80 |
| MDL Number | MFCD00672673 |
| PubChem Substance ID | 24278698 |
| Chemical Name Translation | 4-((R)-((2S,5R)-4-烯丙基-2,5-二甲基哌嗪-1-基)(3-甲氧基苯基)甲基)-N,N-二乙基苯甲酰胺 |
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分类
- {SNA} Bioactive Small Molecule Alphabetical Index, Excitatory Amino Acids - Opiod Agonists, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neurobiology, Neuroscience, Opioid Agonists,
- Pharmaceuticals
- Inhibitors
- Chiral Reagents
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Excitatory Amino Acids - Opiod Agonists, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neurobiology, Neuroscience, Opioid Agonists, Opioids, Pharmacologicals, Proteins and Derivatives, S
- Intermediates & Fine Chemicals
- {SNA} Bioactive Sma
产品应用
- A highly selective and potent non-peptide ?-agonist, 2000-fold selective over u-receptors.
相关文献及参考
- [2]. Bilsky EJ, et al. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist. J Pharmacol Exp Ther. 1995 Apr;273(1):359-66.
- [3]. Calderon SN, et al. Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist. J Med Chem. 1994 Jul 8;37(14):2125-8.
- [4]. Metcalf MD, et al. The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors. ACS Chem Neurosci. 2012 Jul 18;3(7):505-9.
- [5]. Vicente-Sanchez A, et al. The delta opioid receptor tool box. Neuroscience. 2016 Dec 3;338:145-159.
- [6]. Dripps IJ, et al. Role of signalling molecules in behaviours mediated by the δ opioid receptor agonist SNC80. Br J Pharmacol. 2018 Mar;175(6):891-901.
- Bilsky, et al.: J. Pharmacol. Exp. Ther., 273, 359 (1995),
- Kna
