(S)-N-((S)-5-Amino-1-((2-Amino-2-Oxoethyl)Amino)-1-Oxopentan-2-yl)-1-((4R,7S,10S,13S,16R)-7-(2-Amino-2-Oxoethyl)-13-((S)-Sec-Butyl)-16-(4-Ethoxybenzyl)-10-((R)-1-Hydroxyethyl)-6,9,12,15,18-Pentaoxo-1,2-Dithia-5,8,11,14,17-Pentaazacycloicosane-4-Carbonyl)Pyrrolidine-2-Carboxamide (S)-N-((S)-5-氨基-1-((2-氨基-2-氧代乙基)氨基)-1-氧代戊烷-2-基)-1-((4R,7S,10S,13S,16R)-7-(2-氨基-2-氧代乙基)-13-((S)-仲丁基)-16-(4-乙氧基苄基)-10-((R)-1-羟乙基)-6,9,12,15,18-五氧代-1,2-二硫代-5,8,11,14,17-五氮杂环二十烷-4-羰基)吡咯烷-2-甲酰胺

CAS 90779-69-4 MFCD00672436

化学结构图

90779-69-4
SMILES: C[C@@H](CC)[C@@H]1NC(=O)[C@@H](CC2C=CC(=CC=2)OCC)NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O |&1:1,4,8,27,31,39,43,52,56|

化学属性

Mol. FormulaH2
Mol. Weight1

别名和识别编码

Chemical Name(S)-N-((S)-5-Amino-1-((2-Amino-2-Oxoethyl)Amino)-1-Oxopentan-2-yl)-1-((4R,7S,10S,13S,16R)-7-(2-Amino-2-Oxoethyl)-13-((S)-Sec-Butyl)-16-(4-Ethoxybenzyl)-10-((R)-1-Hydroxyethyl)-6,9,12,15,18-Pentaoxo-1,2-Dithia-5,8,11,14,17-Pentaazacycloicosane-4-Carbonyl)Pyrrolidine-2-Carboxamide
Synonym 1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin 1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin 1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin Tractocile 1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin 1-Deamino-2D-tyr-(OEt)-4-thr-8-orn-oxytocin Tractocile
MDL NumberMFCD00672436
PubChem Substance ID24724390
CAS Number90779-69-4
Chemical Name Translation(S)-N-((S)-5-氨基-1-((2-氨基-2-氧代乙基)氨基)-1-氧代戊烷-2-基)-1-((4R,7S,10S,13S,16R)-7-(2-氨基-2-氧代乙基)-13-((S)-仲丁基)-16-(4-乙氧基苄基)-10-((R)-1-羟乙基)-6,9,12,15,18-五氧代-1,2-二硫代-5,8,11,14,17-五氮杂环二十烷-4-羰基)吡咯烷-2-甲酰胺
LabNetwork Molecule IDLN01805812
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
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分类

  • {SNA} AN-AZ, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, Ferring, Fluorination Ready Pharma-Developed Compounds, Hormones, Oxytocin, Pituitary Hormones, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} AN-AZ, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Ferring, Hormones, Oxytocin, Pituitary Hormones
  • AN-AZ, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules,

相关文献及参考

  • Ther Clin Risk Manag. 2010 Apr 26;6:191-9.
  • [2]. Philip J Ryan, et al. Oxytocin-receptor-expressing Neurons in the Parabrachial Nucleus Regulate Fluid Intake. Nat Neurosci. 2017 Dec;20(12):1722-1733.
  • Engstrom, T., et al., Effect of oxytocin receptor blockade on rat myometrial responsivenesss to prostaglandin F 2α . Biol. Reprod. 63 , 1443-1449, (2000) 摘要
  • Merck 14 ,865
  • Tahara, A., et al., Pharmacologic characterization of the oxytocin receptor in human uterine smooth muscle cells. Br. J. Pharmacol. 129 , 131-139, (2000) 摘要
  • Ther Clin Risk Manag. 2010 Apr 26;6:191-9.
  • Wellnitz, O., et al., Atosiban, an oxytocin receptor blocking agent: pharmacokinetics and inhibition of milk ejection in dairy cows. J. Dairy Res. 66 , 1-8, (1999) 摘要
  • [1]. Sanu O, et al. Critical appraisal and clinical utility of atosiban
  • [1]. Sanu O, et al. Critical appraisal and clinical utility of atosiban in the management of preterm labor.

安全信息

WGK Germany3
RTECSRS7590000
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE                    : 94 ug/kg
SEX/DURATION            : female 1-35 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   BJOGAS British Journal of Obstetrics and Gynaecology.  (Blackwell Scientific
   Pub. Ltd., POB 88, Oxford, UK)  V.82-    1975- Volume(issue)/page/year:
   94,1040,1987

系列性分类


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