(S)-N-((S)-5-Amino-1-((2-Amino-2-Oxoethyl)Amino)-1-Oxopentan-2-yl)-1-((4R,7S,10S,13S,16R)-7-(2-Amino-2-Oxoethyl)-13-((S)-Sec-Butyl)-16-(4-Ethoxybenzyl)-10-((R)-1-Hydroxyethyl)-6,9,12,15,18-Pentaoxo-1,2-Dithia-5,8,11,14,17-Pentaazacycloicosane-4-Carbonyl)Pyrrolidine-2-Carboxamide (S)-N-((S)-5-氨基-1-((2-氨基-2-氧代乙基)氨基)-1-氧代戊烷-2-基)-1-((4R,7S,10S,13S,16R)-7-(2-氨基-2-氧代乙基)-13-((S)-仲丁基)-16-(4-乙氧基苄基)-10-((R)-1-羟乙基)-6,9,12,15,18-五氧代-1,2-二硫代-5,8,11,14,17-五氮杂环二十烷-4-羰基)吡咯烷-2-甲酰胺
CAS 90779-69-4 MFCD00672436
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分类
- {SNA} AN-AZ, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, Ferring, Fluorination Ready Pharma-Developed Compounds, Hormones, Oxytocin, Pituitary Hormones, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} AN-AZ, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Ferring, Hormones, Oxytocin, Pituitary Hormones
- AN-AZ, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules,
相关文献及参考
- Ther Clin Risk Manag. 2010 Apr 26;6:191-9.
- [2]. Philip J Ryan, et al. Oxytocin-receptor-expressing Neurons in the Parabrachial Nucleus Regulate Fluid Intake. Nat Neurosci. 2017 Dec;20(12):1722-1733.
- Engstrom, T., et al., Effect of oxytocin receptor blockade on rat myometrial responsivenesss to prostaglandin F 2α . Biol. Reprod. 63 , 1443-1449, (2000) 摘要
- Merck 14 ,865
- Tahara, A., et al., Pharmacologic characterization of the oxytocin receptor in human uterine smooth muscle cells. Br. J. Pharmacol. 129 , 131-139, (2000) 摘要
- Ther Clin Risk Manag. 2010 Apr 26;6:191-9.
- Wellnitz, O., et al., Atosiban, an oxytocin receptor blocking agent: pharmacokinetics and inhibition of milk ejection in dairy cows. J. Dairy Res. 66 , 1-8, (1999) 摘要
- [1]. Sanu O, et al. Critical appraisal and clinical utility of atosiban
- [1]. Sanu O, et al. Critical appraisal and clinical utility of atosiban in the management of preterm labor.
安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE : 94 ug/kg SEX/DURATION : female 1-35 week(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects REFERENCE : BJOGAS British Journal of Obstetrics and Gynaecology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.82- 1975- Volume(issue)/page/year: 94,1040,1987