(2S,3S,4R,5R)-3,4-Dihydroxy-5-(6-((3-Iodobenzyl)Amino)-9H-Purin-9-Yl)-N-Methyltetrahydrofuran-2-Carboxamide (2S,3S,4R,5R)-3,4-二羟基-5-(6-((3-碘苄基)氨基)-9H-嘌呤-9-基)-N-甲基四氢呋喃-2-甲酰胺
CAS 152918-18-8 MFCD00671785
化学结构图
SMILES: CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2C(NCC3C=C(I)C=CC=3)=NC=NC1=2
化学属性
| Mol. Formula | C18H19IN6O4 |
|---|---|
| Mol. Weight | 510.29 |
别名和识别编码
| Chemical Name | (2S,3S,4R,5R)-3,4-Dihydroxy-5-(6-((3-Iodobenzyl)Amino)-9H-Purin-9-Yl)-N-Methyltetrahydrofuran-2-Carboxamide |
|---|---|
| Synonym | 1-Deoxy-1-[6-[((3-Iodophenyl)methyl)amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide 1-Deoxy-1-[6-[((3-Iodophenyl)methyl)amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide N6-(3-Iodobenzyl)adenosine-5'-N-methyluronamide IB-MECA N6-(3-Iodobenzyl)adenosine-5'-N-methyluronamide |
| MDL Number | MFCD00671785 |
| PubChem Substance ID | 24277717 |
| CAS Number | 152918-18-8 |
| Chemical Name Translation | (2S,3S,4R,5R)-3,4-二羟基-5-(6-((3-碘苄基)氨基)-9H-嘌呤-9-基)-N-甲基四氢呋喃-2-甲酰胺 |
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资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Adenosines/P2 Nucleotide Receptors (Purinergics), Agonists, Neuroscience, Neurotransmission, Neurotransmitters, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Adenosines/P2 Nucleotide Receptors (Purinergics), Agonists, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
相关文献及参考
- [2]. Abedi H, et al. Mitochondrial and caspase pathways are involved in the induction of apoptosis by IB-MECA in ovarian cancer cell lines. Tumour Biol. 2014 Nov;35(11):11027-11039.
- [3]. Hofer M, et al. Agonist of the adenosine A3 receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of γ-irradiated mice. Radiat Environ Biophys. 2014 Mar;53(1):211-215.
- [4]. Chandan Sarkar, et al. Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives. Front Pharmacol. 2020; 11: 572870.
- [1]. Shin Y, et al. Activation of Phosphoinositide Breakdown and Elevation of Intracellular Calcium in a Rat RBL-
- [1]. Shin Y, et al. Activation of Phosphoinositide Breakdown and Elevation of Intracellular Calcium in a Rat RBL-2H3 Mast Cell Line by Adenosine Analogs: Involvement of A(3)-Adenosine Receptors? Drug Dev Res. 1996 Sep 1;39(1):36-46.
