CAS 3973-08-8 MFCD00623589-Thiazole-4-carboxylic acid 噻唑-4-甲酸 TAO{mole}

Thiazole-4-carboxylic acid 噻唑-4-甲酸

CAS 3973-08-8 MFCD00623589

化学结构图

SMILES: O=C(O)C1CSCN1

化学属性

Mol. Formula	C4H3NO2S
Mol. Weight	129.14
Melting Point	195-199°C
Appearance	噻唑-4-羧酸是无色固体，m.p.191℃。不溶于水。
Boiling Point	319.2°C at 760 mmHg

别名和识别编码

Chemical Name	Thiazole-4-carboxylic acid
CAS Number	3973-08-8
Alfabeta Name	THIAZOLECARBOXYLICACID 134---,
MDL Number	MFCD00623589
Synonym	4-Thiazolecarboxylic acid {LY} 4-Thiazolecarboxylic acid {} {LY} 4-Thiazolecarboxylic acid {} {} {LY} 4-Thiazolecarboxylic acid {} {} {} {LY} 4-Thiazolecarboxylic acid {} {} {} {} {LY} 4-Thiazolecarboxylic acid {} {} {} {} {} {LY} 4-Thiazolecarboxylic acid {} {} {} {} {} {} {LY} 4-Thiazolecarboxylic acid {} {} {} {} {} {} {} {LY} 4-Thiazolecarboxylic acid {} {} {} {} {} {} {} {} {LY} 4-Thiazolecarboxylic acid {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} 4-Thiazolecarboxylic acid {} {} {} {} {} {} {} {} {} {} {LY} 4-Thiazolecarboxylic acid {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Thiazolecarboxylic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Thiazolecarboxylic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Thiazolecarboxylic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Thiazole
PubChem Substance ID	304271
Chemical Name Translation	噻唑-4-甲酸
Beilstein Registry Number	111080
LabNetwork Molecule ID	LN00008882
InChI	InChI=1S/C4H3NO2S/c6-4(7)3-1-8-2-5-3/h1-2H,(H,6,7)
Canonical SMILES	O=C(O)C1=CSC=N1

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品牌质保精细包装现货库存一流品牌服务

安全信息

Warnings IRRITANT

WGK Germany3

GHS Symbol

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Hazard statements

H317 May cause an allergic skin reaction 可能导致皮肤过敏

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes Xi

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应

Storage condition 2-8°C {LY} 2-8°C Store at room temperature {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°

其他信息

用途二:噻唑-4-羧酸是杀菌剂噻菌灵的中间体。
上游原料:丙酮酸 --> 乙二醇二甲醚 --> 溴代丙酮酸甲酯 --> 硫代甲酰胺 --> 噻唑-4-羧酸甲酯
方法一:其制备方法是用甲酰胺与P 2 S 5 在乙二醇二甲基醚(CH 3 OCH 2 CH 2 OCH 3 )中反应而得到硫代甲酰胺(HCSNH 2 )，再和卤代丙酮酸酯反应而得到产品。将甲酰胺滴加到P 2 S 5 分散在乙二醇二甲基醚溶剂中，温度要低于40℃，大约30min，反应混合物在室温搅拌5h，然后将溴代丙酮酸甲酯在20～30℃滴加到上述溶液中，时间约1h，然后在室温搅拌3h，得到噻唑-4-羧酸甲酯，进一步水解得到产物。
Hazard Note:Irritant
用途一:用作医药、农药中间体，有机合成试剂
MOL 文件:3973-08-8.mol
Sigma Aldrich:3973-08-8(sigmaaldrich)