5-(1-Hydroxy-2-(isopropylamino)ethyl)benzene-1,3-diol 奥西那林

CAS 586-06-1 MFCD00599526

化学结构图

586-06-1
SMILES: CC(C)NCC(O)c1cc(O)cc(O)c1

化学属性

Mol. FormulaC11H17NO3
Mol. Weight211.29

别名和识别编码

Chemical Name5-(1-Hydroxy-2-(isopropylamino)ethyl)benzene-1,3-diol
EC Number209-569-1
Synonym 5-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,3-benzenediol 奥西那林 5-(1-hydroxy-2-propan-2-ylamino-ethyl)benzene-1,3-diol Metaproterenol (base and/or unspecified salts) 3,5-dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol 1,3-Benzenediol, 5-1-hydroxy-2-(1-methylethyl)aminoethyl- 5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-3-benzenediol 5-[2-(Isopropylamino)-1-hydroxyethyl]-1,3-benzenediol 3,5-Dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol 3,5-Dihydroxy-a-[(isopropylamino)methyl]benzyl alcohol 1,3-Benzenediol, 5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)- 5-(1-Hydroxy-2-propan-2-ylamino-ethyl)benzene-1,3-diol; 5-[1-Hydroxy-2-(1-methylethylamino)ethyl]benzene-1,3-diol Orciprenaline Metaproterenol 1,3-Benzenediol, 5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]- (9CI) orciprenaline 5-[1-hydroxy-2-(1-methylethylamino)ethyl]benzene-1,3-diol 5-(1-羟基-2-异丙基氨基乙基)苯-1,3-二酚 1-(3,5-dihydroxyphenyl)-2-isopropylaminoethanol Benzyl alcohol, 3,5-dihydroxy-a-[(isopropylamino)methyl]- (6CI, 8CI) 3,5-Dihydroxy-α-[(isopropylamino)methyl]benzyl alcohol 3,5-dihydroxy-alpha-((isopropylamino)methyl)-benzyl alcohol 间羟异丙基肾上腺素
CAS Number586-06-1
Chemical Name Translation奥西那林
Wiswesser Line NotationQR CQ EYQ1MY
Beilstein Registry Number2807247
PubChem Substance ID4086
InChIInChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-9(13)5-10(14)4-8/h3-5,7,11-15H,6H2,1-2H3
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相关文献及参考

  • [2]. Ibrahim FA, et al. Highly sensitive spectrofluorimetric method for rapid determination of orciprenaline in biological fluids and pharmaceuticals. Luminescence. 2019 Feb;34(1):77-83.
  • [1]. Noh H, et al. Beta 2-adrenergic receptor agonists are novel regulators of macrophage activation in diabetic renal and cardiovascular complications. Kidney Int. 2017 Jul;92(1):101-113.
  • [1]. Noh H, et al. Beta 2-adrenergic receptor agonists are novel regulators of macrophage activation in diabetic renal and cardiovascular complications. Kidney Int. 2017 Jul;92(1):101-113.
  • [2]. Ibrahim FA, et al. Highly sensitive spectrofluorimetric method for rapid determination of orciprenaline in biological fluids and pharmaceuticals. Luminescence. 2019 Feb;34(1):77-83.

安全信息

RTECSDO1800000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 67200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   8,353,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 3110 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   8,353,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 286 ug/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Cardiac - arrhythmias (including changes in conduction)
   Vascular - BP elevation not characterized in autonomic section
REFERENCE :
   AJMSA9 American Journal of the Medical Sciences.  (Slack Inc., 6900 Grove
   Rd., Thorofare, NJ 08086) New series: V.1-    1841- Volume(issue)/page/year:
   291,168,19

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   8,353,1

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 800 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   RDCNBM Reproduccion.  (Madrid, Spain)  V.1-7, 1974-83.  Discontinued.
   Volume(issue)/page/year: 5,31,1981

其他信息

  • 用途一:支气管扩张药。
  • 方法一:3，5-二乙酸基乙酰首先与溴反应，然后与异丙胺反应得过且过-（3，5-二羟基苯基）-2-异丙胺乙酮，将其溶于甲醇，在室温下以镍催化氢化，得异丙喘宁。
  • MOL 文件:586-06-1.mol
  • 上游原料:丙酮 --> 异丙胺 --> 异丙喘宁

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adrenergic Receptor  (肾上腺素能受体)

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