4-Hydroxy-N'-(4-Isopropylbenzylidene)Benzohydrazide (E)-4-羟基-N’-(4-异丙基亚苄基)苯并酰肼
CAS 101574-65-6 MFCD00567155
化学结构图
SMILES: CC(C)C1C=CC(/C=N/NC(=O)C2C=CC(O)=CC=2)=CC=1
化学属性
| Mol. Formula | C17H18N2O2 |
|---|---|
| Mol. Weight | 282.34 |
别名和识别编码
| Chemical Name | 4-Hydroxy-N'-(4-Isopropylbenzylidene)Benzohydrazide |
|---|---|
| Synonym | 2-[[4-(1-Methylethyl)phenyl]methylene]hydrazide 4-hydroxybenzoic acid GSK 4716 |
| MDL Number | MFCD00567155 |
| CAS Number | 101574-65-6 |
| PubChem Substance ID | 329799950 |
| Chemical Name Translation | (E)-4-羟基-N’-(4-异丙基亚苄基)苯并酰肼 |
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分类
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Estrogen, G, GlaxoSmithKline, Hormones, Steroid Hormones
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, Estrogen, Fluorination Ready Pharma-Developed Compou
- Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Estrogen, G, GlaxoSmithKline, Hormones, Steroid Hormones
相关文献及参考
- Ariazi, E.A., et al., Estrogen-related receptors as emerging targets in cancer and metabolic disorders. Curr. Top. Med. Chem 6 , 203-15, (2006) 摘要
- Wang, S.C., et al., An ERRbeta/gamma agonist modulates GRalpha expression, and glucocorticoid responsive gene expression in skeletal muscle cells. Mol. Cell. Endocrinol. , (2009)
- Zuercher, W.J., et al., Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. J. Med. Chem. 48 , 3107-9, (2005) 摘要
安全信息
GHS Symbol
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
- R50/53
