Phomopsin A
CAS 64925-80-0 MFCD00467142
化学结构图
SMILES: CN[C@@H]1[C@H](O)C2=CC(O[C@](C)(CC)[C@H](NC(=O)[C@@H](NC1=O)C(C)=C)C(=O)N1CC=C[C@H]1C(=O)N/C(/C(=O)N/C(=C/C(O)=O)/C(O)=O)=C(\C)/CC)=C(O)C(Cl)=C2
化学属性
| Mol. Formula | C36H45ClN6O12 |
|---|---|
| Mol. Weight | 789.23 |
别名和识别编码
| Chemical Name | Phomopsin A |
|---|---|
| MDL Number | MFCD00467142 |
| CAS Number | 64925-80-0 |
| Chemical Name Translation |
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相关文献及参考
- [1]. Hamel E, et al. Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B. Pharmacol Ther. 1992;55(1):31-51.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 61,105,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - domestic
DOSE/DURATION : 10 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AUVJA2 Australian Veterinary Journal. (Australian Veterinary Assoc.,
Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2-
1927- Volume(issue)/page/year: 64,293,1987TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Mammal - domestic
DOSE/DURATION : 1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AUVJA2 Australian Veterinary Journal. (Australian Veterinary Assoc.,
Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2-
1927- Volume(issue)/page/year: 64,293,1987TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Mammary gland DOSE/DURATION : 1 umol/L REFERENCE : JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 16,13,1985
TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 1 mg/L REFERENCE : CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 46,79,1986
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 10 mg/L REFERENCE : CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 46,79,1986
TYPE OF TEST : Micronucleus test TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 5 mg/L REFERENCE : CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 46,79,1986
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 10 mg/L REFERENCE : CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 46,79,1986
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 400 ug/kg SEX/DURATION : female 6 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 61,105,1983
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 150 ug/kg SEX/DURATION : female 6-10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 61,105,1983
GHS Symbol
