CAS 52214-84-3 MFCD00467135-2-(4-(2,2-Dichlorocyclopropyl)Phenoxy)-2-Methylpropanoic Acid 2-(4-(2,2-二氯环丙基)苯氧基)-2-甲基丙酸 TAO{mole}

2-(4-(2,2-Dichlorocyclopropyl)Phenoxy)-2-Methylpropanoic Acid 2-(4-(2,2-二氯环丙基)苯氧基)-2-甲基丙酸

CAS 52214-84-3 MFCD00467135

化学结构图

SMILES: CC(C)(OC1C=CC(=CC=1)C1CC1(Cl)Cl)C(O)=O

化学属性

Mol. Formula	C13H14Cl2O3
Mol. Weight	289
Melting Point	118

别名和识别编码

Chemical Name	2-(4-(2,2-Dichlorocyclopropyl)Phenoxy)-2-Methylpropanoic Acid
CAS Number	52214-84-3
Synonym	(?)-Ciprofibrate 2-(p-(2,2-Dichlorocyclopropyl)phenoxy)-2-methyl propionic acid 2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic Acid 2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropionic acid 2-[p-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid 2-[p-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropionic Acid Ciprofibrate Ciprol Lipanor Modalim WIN 35833
MDL Number	MFCD00467135
PubChem Substance ID	160871346
EC Number	257-744-6
Chemical Name Translation	2-(4-(2,2-二氯环丙基)苯氧基)-2-甲基丙酸
Wiswesser Line Notation	L3TJ AG AG BR DOX1&1&VQ
Beilstein Registry Number	1984981
Reaxys-RN	1984981
Merck Number	2313

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产品应用

Ciprofibrate is a hypolipemic agent, related structurally to Clofibrate (C586910). Ciprofibrate is used as an antilipemic.

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P308+P313

Hazard statements

H350 May cause cancer 可能致癌

RTECSUF0880000

Signal word Danger

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Hazard Codes T

Risk Statements

R45 May cause cancer 可能致癌

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6390 mg/kg/60W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   38,65,1987

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7300 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   TOPADD Toxicologic Pathology.  (c/o Dr. F.A. de la Iglesia, Warner-Lambert
   Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 
     1978-  Volume(issue)/page/year: 17,7,1989

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6720 mg/kg/64W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   32,33,1986

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 1400 mg/kg/14D (Continuous)
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   78,235,1991

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 286,135,1993

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 286,135,1993

TYPE OF TEST            : Morphological transformation
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 3650 mg/kg/1Y (Continuous)
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   46,4601,1986

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 105 mg/kg/7D (Continuous)
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   47,21,1989

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 250 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 280 mg/kg
SEX/DURATION            : female 15-21 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 12,1,1979

Storage condition 0-10°C