CAS 59865-13-3 MFCD00274558-Cyclosporin A 环胞霉素 TAO{mole}

Cyclosporin A 环胞霉素

CAS 59865-13-3 MFCD00274558

化学结构图

SMILES: C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C

化学属性

Mol. Formula	C62H111N11O12
Mol. Weight	1203
Appearance	从-15℃的丙酮得白色针状结晶，熔点148～151℃，[α] D 20 小鼠，大鼠，兔子(mg/kg)：107，25，＞10静脉注射；2329，1480，＞1000口服。 -244°(C=0.6，氯仿)。溶于甲醇、乙醇、丙酮、乙醚或氯仿，微溶于水及饱和碳氢化合物。急性毒性LD 50
Melting Point	151
Density	1.016

别名和识别编码

Chemical Name	Cyclosporin A
CAS Number	59865-13-3
Synonym	Sandimmun(e) Sandimmune 环孢菌素 A Ramihyphin A Cyclosporine A 环孢霉素抗生素 S 7481F1 环孢霉素 OL 27-400 Cyclosporine 出地明 Restasis Antibiotic S 7481F1 Atopica Ciclosporin S 7481F1 环孢菌素, 环孢素, 抗生素S 7481F1,环孢多肽A 环孢灵抗生素 S 7481F1
PubChem Substance ID	125307331
Beilstein Registry Number	3647785
MDL Number	MFCD00274558
Reaxys-RN	3647785
Merck Number	2752
Chemical Name Translation	环胞霉素
LabNetwork Molecule ID	LN00236320

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分类

{SNA} Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, CI-CZ, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators, Immunomodulators and Antibiotics,

产品应用

抑制T细胞受体信号传导路径,用于分子生物学研究。

安全信息

GHS Symbol

WGK Germany3

Hazard Codes T

Hazard statements

H302 Harmful if swallowed 吞食有害
H350 May cause cancer 可能致癌
H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RTECSGZ4120000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312+P330
P308+P313
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word

Storage condition 0-10 0-10°C 储存温度：2-8°C

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Risk Statements

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 259 mg/kg/2W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   CEDEDE Clinical and Experimental Dermatology.  (Blackwell Scientific Pub.
   Ltd., POB 88, Oxford, UK) V.1-    1976-  Volume(issue)/page/year: 8,159,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 20 mg/kg/2D-I
TOXIC EFFECTS :
   Behavioral - headache
   Vascular - acute arterial occlusion
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,1092,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOPADD Toxicologic Pathology.  (c/o Dr. F.A. de la Iglesia, Warner-Lambert
   Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 
     1978-  Volume(issue)/page/year: 14,73,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 30 mg/kg/4D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   107,786,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 62500 ug/kg/5D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,1221,1986

TYP

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 320,217,1994

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1 mg/L
REFERENCE :
   IGAYAY Igaku No Ayumi.  Progress in Medicine.  (Ishiyaku Shuppan K.K.,
   1-7-10, Honkomagom, Bunkyo-ku, Tokyo, Japan)  V.1-    1946-
   Volume(issue)/page/year: 134,403,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 420 mg/kg
SEX/DURATION            : male 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 109,75,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 166 mg/kg
SEX/DURATION            : male 45 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - other effects on male
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   JOAND3 Journal of Andrology.  (Lippincott/Harper, Journal

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 50 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   JCGBDF Journal of Craniofacial Genetics and Developmental Biology.  (Alan R.
   Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1980-
   Volume(issue)/page/year: 12,155,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF E

其他信息

无臭无味。本品在甲醇、乙醇或乙腈中极易溶解，在醋酸乙酯中易溶，在丙酮或乙醚中溶解，在水中几乎不溶。