LY294002 2-吗啉代-8-苯基色酮
CAS 154447-36-6 MFCD00270881
化学结构图
SMILES: O=c1cc(N2CCOCC2)oc2c(-c3ccccc3)cccc12
化学属性
| Mol. Formula | C19H17NO3 |
|---|---|
| Mol. Weight | 307 |
| Melting Point | 182.0-186.0 |
别名和识别编码
| Chemical Name | LY294002 |
|---|---|
| Synonym | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one LY 29400 LY 294002 LY 294002, 2-Morpholino-8-phenyl-4-oxo-4H-1-benzopyran LY-294002 LY294002 |
| MDL Number | MFCD00270881 |
| PubChem Substance ID | 3973 |
| CAS Number | 154447-36-6 |
| Chemical Name Translation | 2-吗啉代-8-苯基色酮 |
| Beilstein Registry Number | 8156139 |
| Reaxys-RN | 8156139 |
| LabNetwork Molecule ID | LN01291396 |
| InChI | InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 |
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资金保障
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分类
- {SNA} Autophagy, Autophagy In
- {SNA} Autophagy, Autophagy Inhibitors, Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Inositol Phosphates, Kinase/Phosphatase Biology, L, Lipids in Cell Signaling, P to Q, PI3K-Akt-mTOR Enzyme Regulators, Phosphatidylinositol 3-kinase, Phosphatidylinositol 3-kinase (PI3K), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, Small Molecules for Stem Cell Biology, 干细胞生物学, 生化试剂, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学, 肿瘤生长调节, 酶、抑制剂和底物
相关文献及参考
- Vlahos, C.J., et al., A specific inhibitor of phosphatidylinositol 3-kinase 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269 , 5241, (1994) 摘要
- Brunn, G.J., et al., Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J. 15 , 5256-5267, (1996) 摘要
- Vlahos, C.J., et al., Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase. J. Immunol. 154 , 2413-2422, (1995) 摘要
- Bulat, N., et al., LDLs Stimulate P38 MAPKs And Wound Healing Through SR-BI Independently Of Ras And PI3 Kinase. J. Lipid Res. 50 , 81-9, (2009) 摘要
- Petersen, S.L., et al., Overcoming Cancer Cell Resistance To Smac Mimetic Induced Apoptosis By Modulating CIAP-2 Expression. Proc. Natl. Acad. Sci. U. S. A. 107 , 11936-41, (2010) 摘要
- Kolegraff, K., et al., Loss Of Desmocollin-2 Confers A Tumorigenic Phenotype To Colonic Epithelial Cells Through Activation Of Akt/β-catenin Signaling Mol. Biol. Cell 22 , 1121-1134, (2011) 摘要
- Dutta, D., et al., Self-renewal Versus Lineage Commitment Of Embryonic Stem Cells: Protein Kinase C Signaling Shifts The Balance. Stem Cells 29 , 618-28, (2011) 摘要
安全信息
GHS Symbol
- S24 Avoid contact with skin 避免皮肤接触；
- S25 Avoid contact with eyes 避免眼睛接触；
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
