rac-Mephenytoin (S)-5-乙基-3-甲基-5-苯基咪唑烷-2,4-二酮
CAS 70989-04-7 MFCD00270025
化学结构图
SMILES: CCC1(NC(=O)N(C)C1=O)C1C=CC=CC=1
化学属性
| Mol. Formula | C12H14N2O2 |
|---|---|
| Mol. Weight | 218 |
| Melting Point | 135-138 °C |
| Appearance | solid 白色结晶性粉末。熔点136-137℃。易溶于氯仿，溶于醇、醚，不溶于水。无臭、无味。 |
别名和识别编码
| Chemical Name | rac-Mephenytoin |
|---|---|
| CAS Number | 70989-04-7 |
| Synonym | (+)-Mephenytoin (+/-)-5-ETHYL-3-METHYL-5-PHENYL-2,4-IMIDAZOLIDINEDIONE (+/-)-MEPHENYTOIN (5S)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione (S)-(+)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione (S)-(+)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione (S)-(+)-5-Ethyl-3-methyl-5-phenylhydantoin (S)-(+)-5-Ethyl-3-methyl-5-phenylhydantoin 2,4-Imidazolidinedione, 5-ethyl-3-methyl-5-phenyl- 3-Ethylnirvanol 3-Methyl-5,5-ethylphenylhydantoin 5-Ethyl-3-methyl-5-phenyl-2,4(3H,5H)-imidazoledione 5-Ethyl-3-methyl-5-phenylimidazolidin-2,4-dione 5-ethyl-3-methyl-5-phenyl-4-imidazolidinedione 5-ethyl-3-methyl-5-phenyl-hydantoi 5-乙基于-3-甲基-5-苯基乙内酰脲 MEPHENYTOIN Β-甲基乙內醯脲 美芬妥因 美芬妥英 |
| MDL Number | MFCD00270025 |
| PubChem Substance ID | 24724646 |
| Chemical Name Translation | (S)-5-乙基-3-甲基-5-苯基咪唑烷-2,4-二酮 |
| EC Number | 200-012-8 |
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分类
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Drug and Xenobiotic Metabolism, M, Multi-Drug Resistance and Drug Metabolism, Substrates, Inducers, Inhibitors
- Heterocycles
- Pharmaceuticals
- {SNA} Bioactive Small Molecule Alphabetical Index, Drug and Xenobiotic Metabolism, M, Multi-Drug Resistance and Drug Metabolism, Substrates, Ind
产品应用
- An anticonvulsant agent.
相关文献及参考
- Shimada, et al.: Anal. Biochem., 147, 174 (1975),
- Dzhagatspanyan. IA., et al.: Pharm. Chem. J., 25, 181 (1991),
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R22 Harmful if swallowed 吞咽有害
其他信息
- MOL 文件:50-12-4.mol
- 上游原料:氰化钾 --> 稀盐酸 --> 碳酸铵 --> 苯丙酮 --> 氰化物
- 方法一:由苯丙酮环合、甲基化而得。1.环合将碳酸铵、氰化钾、氨水依次加入苯丙酮和乙醇的混合液中，加热反应后，将反应物放入冰水中，加稀盐酸至pH为5-6，析了白色粉末。过滤，滤液加硫酸亚铁水溶液破坏氰化物。滤饼用水洗至中性，干燥，得5-乙基-5-苯基乙内酰脲。2.甲基化将5-乙基-5-苯基乙内酰脲溶于氢氧化钠溶液中，缓缓加入硫酸二甲酯，在12-15℃反应2h至反应液为中性。过滤，滤饼先后用10%氢氧化钠溶液和水洗涤，干燥得美芬妥英粗品。精制而得成品。
- color:off-white
- 用途一:该品为抗癫痫病。大鼠腹腔注射LD50为270mg/kg。
- Sigma Aldrich:50-12-4(sigmaaldrich)
