CAS 1951-25-3 MFCD00242801-(2-Butylbenzofuran-3-Yl)(4-(2-(Diethylamino)Ethoxy)-3,5-Diiodophenyl)Methanone (2-丁基苯并呋喃-3-基)(4-(2-(二乙基氨基)乙氧基)-3,5-二碘苯基)甲酮 TAO{mole}

(2-Butylbenzofuran-3-Yl)(4-(2-(Diethylamino)Ethoxy)-3,5-Diiodophenyl)Methanone (2-丁基苯并呋喃-3-基)(4-(2-(二乙基氨基)乙氧基)-3,5-二碘苯基)甲酮

CAS 1951-25-3 MFCD00242801

化学结构图

SMILES: CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1

化学属性

Mol. Formula	C25H29I2NO3
Mol. Weight	645.31
Appearance	其盐酸盐[19744-82-4]为白色至微带黄白色结晶性粉末。熔点156℃。几乎不溶于水，易溶于氯仿，溶于乙醇，微溶于丙酮。无臭，无味。
Melting Point	54 - 55°C
Boiling Point
Flash Point	-

别名和识别编码

Chemical Name	(2-Butylbenzofuran-3-Yl)(4-(2-(Diethylamino)Ethoxy)-3,5-Diiodophenyl)Methanone
EC Number	217-772-1
Synonym	(2-Butylbenzofuran-3-yl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone (2-butyl-3-benzofuranyl)(4-(2-(diethylamino)ethoxy)-3,5-diidophenyl)methanone 2-BUTYL-3-BENZOFURANYL 4-[2-(DIETHYLAMINO)-ETHOXY]-3,5-DIIODOPHENYL KETONE 2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran 2-Butyl-3-(3,5-diiodo-4-(beta-diethylaminoethoxy)benzoyl)benzofuran 2-Butyl-3-(4'-beta-N-diethylaminoethoxy-3',5'-diiodobenzoyl)benzofuran 2-Butyl-3-benzofuranyl p-((2-diethylamino)ethoxy)-m,m-diiodophenyl ketone 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone 2-butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran 2-butyl-3-(3,5-diiodo-4-(beta-diethylaminoe 2-butyl-3-(3,5-diiodo-4-(beta-diethylaminoethoxy)benzoyl)benzofuran 2-butyl-3-(4’-beta-n-diethylaminoethoxy-3’,5’-diiodobenzoyl
CAS Number	1951-25-3
MDL Number	-
Chemical Name Translation	(2-丁基苯并呋喃-3-基)(4-(2-(二乙基氨基)乙氧基)-3,5-二碘苯基)甲酮
Wiswesser Line Notation	T56 BOJ C4 DVR CI EI DO2N2&2
Beilstein Registry Number	1271711
LabNetwork Molecule ID	LN00200943
Canonical SMILES	-

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安全信息

Hazard Codes Xn

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

Storage condition +4°C 2-8°C 4 4°C 4℃

WGK Germany3

RTECSOB1360000

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 1714 mg/kg/21W-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - cough
   Lungs, Thorax, or Respiration - cyanosis
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NEJMAG New England Journal of Medicine.  (Massachusetts Medical Soc., 10
   Shattuck St., Boston, MA 02115)  V.198-    1928-  Volume(issue)/page/year:
   308,779,1983

{h

{hazard_c

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 48 mg/kg/3D-I
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
REFERENCE :
   AHJOA2 American Heart Journal.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63146) V.1-    1925-  Volume(issue)/page/year:
   130,399,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 57 mg/kg/5D-I
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   97,561,1982

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 1869 mg/kg/22W-I
TOXIC EFFECTS :
   Behavioral - coma
   Vascular - BP lowering not characterized in autonomic section
   Endocrine - evidence of thyroid hypofunction
REFERENCE :
   AJMEAZ American Journal of Medicine.  (Technical Pub., 875 Third Ave., New
   York, NY 10022) V.1-    1946-  Volume(issue)/page/year: 77,751,1984

TYPE OF TEST

其他信息

MOL 文件:1951-25-3.mol
储运特性:库房通风低温干燥
方法一:以邻羟基苯甲醛为原料，与1-溴戊酮-2一环合，用水合肼还原，与对甲氧苯甲酰氯缩合，然后水解，碘化，与二乙氨基氯乙烷醚化而得。文献报道的一种醚化操作如下：取135g2-丁基-3（3,5-二碘-4-羟基苯甲酰基）苯并呋喃溶于600ml碳酸乙酯中，以5.7g金属钠制成的甲醇钠的甲醇溶液处理。然后将由51.6gβ-二乙氨基乙基氯盐酸盐于碳酸乙酯中制得的β-二乙氨基乙基氯加入上述钠盐的悬浮液中，混合物加热至温度约90℃并保温约2h，冷却放置过夜，在此期间使氯化钠沉淀完全。含乙胺碘呋喃酮的反应液经纯化、成盐、即得盐酸乙胺碘呋酮。
毒性分级:高毒
MSDS 信息:Amiodarone(1951-25-3).msds
上游原料:碳酸二乙酯 --> 2-羟基苯甲醛 --> 甲醇钠的甲醇溶液 --> 对甲氧基苯甲酰氯 --> 呋喃酮 --> 戊酮-2 --> 2-丁基-3-(3,5-二碘-4-羟基苯甲酰基)苯并呋喃 --> 盐酸胺碘酮 --> 二乙氨基乙基氯盐酸盐
类别:易燃液体
急性毒性:腹腔-小鼠LD50: 254 毫克/公斤; 静脉-小鼠LD50: 178 毫克/公斤
灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
用途一:用作抗心律失常、心绞痛药
Sigma Aldrich:1951-25-3(sigmaaldrich)
用途二:该品为抗心律失常药物。用于各种房性和室性心律失常（包括严重充血性心力衰竭和急性心肌梗塞并发的心律失常）；对服用其他抗心律失常药物无效的病人，服用该品则有明显的效果。该品也可用于冠心病、心绞痛和胸闷的治疗。该品安全范围较其抗心律失常药为大。小鼠静脉注射LD50为160mg/kg，小鼠口服LD50为50g/kg。因此该品以口服治疗时属无毒药物。常见的不良反应有恶心、呕吐、便秘、心动过缓和皮疹等。
可燃性危险特性:可燃;燃烧产生有毒氮氧化物和碘化物烟雾