CAS 78755-81-4 MFCD00242764-Flumazenil 氟马西尼 TAO{mole}

Flumazenil 氟马西尼

CAS 78755-81-4 MFCD00242764

化学结构图

SMILES: CN1CC2=C(N=CN2C2C=CC(F)=CC=2C1=O)C(=O)OCC

化学属性

Mol. Formula	C15H14FN3O3
Mol. Weight	303.29
TSCA	No
Melting Point	198.0 to 202.0 deg-C

别名和识别编码

Chemical Name	Flumazenil
CAS Number	78755-81-4
Synonym	Flumazenil Flumenazil Ro 151788 Ro 15-1788 Anexate Flumazepil Lanexat Mazicon Ethyl Ro 172 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic Acid Ethyl Ester Ro 15-1788/000
MDL Number	MFCD00242764
PubChem Substance ID	253662580
Merck Number	4135
Chemical Name Translation	氟马西尼
Beilstein Registry Number	4763661
LabNetwork Molecule ID	LN01310597
Reaxys-RN	4763661

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产品应用

Imidazodiazepine which selectively blocks the central effects of classic benzodiazepines. It is used as benzodiazepine antagonist.

安全信息

RTECSN12922170

WGK Germany3

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

TYPE OF TEST            : TD

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 5700 ng/kg/C
TOXIC EFFECTS :
   Cardiac - cardiomyopathy including infarction
   Cardiac - arrhythmias (including changes in conduction)
   Cardiac - change in rate
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavisto

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1300 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JTCEEM Journal de Toxicologie Clinique et Experimentale.  (SPPIF, B.P.22,
   F-41353 Vineuil, France) V.5-    1985-  Volume(issue)/page/year: 7,223,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JTCEEM Journal de Toxicologie Clinique et Experimentale.  (SPPIF, B.P.22,
   F-41353 Vineuil, France) V.5-    1985-  Volume(issue)/page/year: 7,223,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JTCEEM Journal de Toxicologie Clinique et Experimentale.  (SPPIF, B.P.22,
   F-41353 Vineuil, France) V.5-    1985-  Volume(issue)/page/year: 7,223,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 220 mg/kg
SEX/DURATION            : female 11-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   GEPHDP General Pharmacology.  (Pergamon Press Inc., Maxwell House, Fairview
   Park, Elmsford, NY 10523) V.6-    1975-  Volume(issue)/page/year: 22,43,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 21 mg/kg
SEX/DURATION            : female 14-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   PNPPD7 Progress in Neuro-Psychopharmacology and Biological Psychiatry.
   (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6-
      1982-  Volume(issue)/page/year: 17,151,1993

GHS Symbol

UN Number

Hazard Codes

Signal word

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P273 Avoid release to the environment. 避免释放到环境中。
P301+P312
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P330 Rinse mouth. 漱口
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Packing GroupIII

Hazard statements

H303 May be harmfully swallowed 吞食可能有害

Storage condition 0-10°C