N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester N-乙酰基-1-色氨酸3,5-双(三氟甲基)苄酯
CAS 148451-96-1 MFCD00237267
化学结构图
SMILES: CC(=O)N[C@@H](CC1=CNC2C=CC=CC1=2)C(=O)OCC1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F
化学属性
| Mol. Formula | C22H18F6N2O3 |
|---|---|
| Mol. Weight | 472.38 |
| Melting Point | 147-148 °C(lit.) |
别名和识别编码
| Chemical Name | N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester |
|---|---|
| Synonym | L-732,138 |
| MDL Number | MFCD00237267 |
| PubChem Substance ID | 24277690 |
| CAS Number | 148451-96-1 |
| Chemical Name Translation | N-乙酰基-1-色氨酸3,5-双(三氟甲基)苄酯 |
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分类
- A-AM, Antagonist, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Proteins and Derivatives, Tachykinins, Tachykinnin - Receptor Antagonists
- {SNA} A-AM, Antagonist, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools,
- {SNA} Antagonist,
- {SNA} Antagonist,
相关文献及参考
- [2]. Cascieri MA, et al. Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor. J Biol Chem. 1994 Mar 4;269(9):6587-91.
- [3]. Kuo HP, et al. Lipopolysaccharide enhances neurogenic plasma exudation in guinea-pig airways. Br J Pharmacol. 1998 Oct;125(4):711-6.
- Cascieri, M. A., Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor. J. Biol. Chem. 269 , 6587, (1994) 摘要
- MacLeod, A. M., Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor. J. Med. Chem. 37 , 1269, (1994) 摘要
- MacLeod, A. M., N-acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists. J. Med. Chem. 36 , 2044, (1993)
- [1]. Muñoz M, et al. The NK-1 Receptor Antagonist L-732,138 Induces Apoptosis and Counteracts Substance P-Related Mitogenesis in Human Me
