Dolastatin 15
CAS 123884-00-4 MFCD00236968
化学结构图
SMILES: CN(C)[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O[C@@H](C(C)C)C(=O)N1[C@@H](CC2C=CC=CC=2)C(=CC1=O)OC
化学属性
| Mol. Formula | C45H68N6O9 |
|---|---|
| Mol. Weight | 837.06 |
别名和识别编码
| Chemical Name | Dolastatin 15 |
|---|---|
| Synonym | (5S)-1-[(2S)-O-(N,N-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline Dolastatin 15 |
| MDL Number | MFCD00236968 |
| PubChem Substance ID | 24893943 |
| CAS Number | 123884-00-4 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {SNA} Cytoskeleton and Extracellular Matrix, Microtubule Inhibitors, 抗肿瘤药物, 癌症研究, 细胞信号转导和神经科学, 细胞生物学
- {SA} Antitumor Agents, Bioactive Small Molecules, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, DIG-DY, Microtobule Inhibitors, Microtubule Inhibitors
- {SNA} Antitumor Agents, Bioactive Small Molecules, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, DIG-DY, Microtubule Inhibitors
相关文献及参考
- [2]. Sato M, et al. A natural peptide, dolastatin 15, induces G2/M cell cycle arrest and apoptosis of human multiple myeloma cells. Int J Oncol. 2007 Jun;30(6):1453-9.
- [3]. Gianolio DA, et al. Targeting HER2-positive cancer with dolastatin 15 derivatives conjugated to trastuzumab, novel antibody-drug conjugates. Cancer Chemother Pharmacol. 2012 Sep;70(3):439-49.
- [4]. Ali MA, et al. Dolastatin 15 induces apoptosis and BCL-2 phosphorylation in small cell lung cancer cell lines. Anticancer Res. 1998 Mar-Apr;18(2A):1021-6.
- [1]. Bai R, et al. Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules. Biochem Pharmacol. 1992 Jun 23;43(12):2637-45.
- [1]. Bai R, et al. Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules. Biochem Pharmacol. 1992 Jun 23;43(12):2637-45.
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