3-{1-[3-(Amidinothio)Propyl]-3-Indolyl}-4-(1-Methyl-3-Indolyl)-1H-Pyrrole-2,5-Dione Methanesulfonate 3-(3-(4-(1-甲基-1H-吲哚-3-基)-2,5-二氧代-2,5-二氢-1H-吡咯-3-基)-1H-吲哚-1-基)丙基异硫脲甲磺酸盐
CAS 138489-18-6 MFCD00236436
化学结构图
SMILES: CN1C=C(C2=C(C3=CN(CCCSC(N)=N)C4C=CC=CC3=4)C(=O)NC2=O)C2C=CC=CC1=2
化学属性
| Mol. Formula | C26H27N5O5S2 |
|---|---|
| Mol. Weight | 553.652 |
| Appearance | Yellow to orange solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 3-{1-[3-(Amidinothio)Propyl]-3-Indolyl}-4-(1-Methyl-3-Indolyl)-1H-Pyrrole-2,5-Dione Methanesulfonate |
|---|---|
| CAS Number | 138489-18-6 |
| Formula | C26H27N5O5S2 |
| Synonym | RO31-8220; RO 31-8220; RO31-8220; RO318220; RO-318220; RO 318220; RO31-8220 mesylate; Bisindolylmaleimide IX; BIM IX. |
| IUPAC Name | 3-(3-(4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-1H-indol-1-yl)propyl carbamimidothioate methanesulfonate |
| InChIKey | SAWVGDJBSPLRRB-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H23N5O2S.CH4O3S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20;1-5(2,3)4/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32);1H3,(H,2,3,4) |
| Chemical Name Translation | 3-(3-(4-(1-甲基-1H-吲哚-3-基)-2,5-二氧代-2,5-二氢-1H-吡咯-3-基)-1H-吲哚-1-基)丙基异硫脲甲磺酸盐 |
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产品应用
- Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%. Ro-31-8220 showed the apoptotic effect on HL-60 cells, which was mediated by a well-characterized transduction process of apoptotic signals: i.e., mitochondrial cytochrome c efflux and the activation of caspase-3 in the cytosol. Moreover, the ability of Ro-31-8220 to induce apoptotic activation was completely inhibited by the over-expression of the apoptotic suppressor gene, Bcl-2, in the cells.
