Sulprostone

CAS 60325-46-4 MFCD00216056

化学结构图

60325-46-4
SMILES: CS(=O)(=O)NC(=O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)COC2C=CC=CC=2)[C@H](O)CC1=O

化学属性

Mol. FormulaC23H31NO7S
Mol. Weight465.56

别名和识别编码

Chemical NameSulprostone
Synonym (5Z,11α,13E,15R)--11,15-Dihydroxy-9-oxo-16-phenoxy-17,18,19,20-tetranorprosta-5,13-dienoic acid methane sulfonamide CP-34089 SHB-286 ZK-57671 (5Z,11α,13E,15R)--11,15-Dihydroxy-9-oxo-16-phenoxy-17,18,19,20-tetranorprosta-5,13-dienoic acid methane sulfonamide (5Z,11α,13E,15R)--11,15-Dihydroxy-9-oxo-16-phenoxy-17,18,19,20-tetranorprosta-5,13-dienoic acid methane sulfonamide CP-34089 SHB-286 ZK-57671 16-Phenoxy-omega-17,18,19,20-tetranor pge-2 methylsulfonylamide 16-Phenoxy-omega-17,18,19,20-tetranor prostaglandin E2 CP 34089 CP-34089 SHB-286 ZK-57671
CAS Number60325-46-4
PubChem Substance ID24724621
EC Number262-173-0
MDL NumberMFCD00216056
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分类

  • Analytical Standards, Analytical/Chromatography, Arachidonic Acid Cascade, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, Eicosanoids (Prostaglandins, Leukotrienes), Fatty Acyls, Forensic and Veterinary Standards, Lipids, Lipids in Cell Signaling, Neat Compounds, Others, Prostaglandins, S
  • {SA} Analytical Standards, Analytical/Chromatography, Arachidonic Acid Cascade, Bioactive Small Molecules, Biochemicals and Reagents,
  • {SNA} Arachidonic Acid Cascade,

相关文献及参考

  • [2]. Jenny Bulgarelli, et al. Skewing effect of sulprostone on dendritic cell maturation compared with dinoprostone. Cytotherapy. 2018 Jun;20(6):851-860.
  • [3]. Yifan Shi, et al. Bioanalysis of sulprostone, a prostaglandin E 2 analogue and selective EP 3 agonist, in monkey plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:51-57.
  • Boie, Y., et al, Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur. J. Pharmacol. 340 , 227-241 , (2002) 摘要
  • Hatae, N., et al, Augmentation of receptor-mediated adenylyl cyclase activity by Gi-coupled prostaglandin receptor subtype EP3 in a Gβγ subunit-dependent manner. Biochem. Biophys. Res. Commun. 290 , 162-168 , (2002)
  • Merck 14 ,8991
  • [1]. S Nar
  • [1]. S Narumiya, et al. Prostanoid receptors: structures, properties, and functions. Physiol Rev. 1999 Oct;79(4):1193-226.

安全信息

GHS Symbol
WGK Germany3
Hazard Codes T
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSMJ8810000
Precautionary statements
  • P305+P351+P338
  • P308+P313
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S22 Do not breathe dust 不要吸入粉尘；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R60 May impair fertility 可能降低生殖能力
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya.  Experimental and
   Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049
   Moscow, Russia)  V.55-    1992-  Volume(issue)/page/year: 56(4),37,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 12 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya.  Experimental and
   Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049
   Moscow, Russia)  V.55-    1992-  Volume(issue)/page/year: 56(4),37,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya.  Experimental and
   Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049
   Moscow, Russia)  V.55-    1992-  Volume(issue)/page/year: 56(4),37,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraplacental
SPECIES OBSERVED        : Human - woman
DOSE                    : 500 ng/kg
SEX/DURATION            : female 15 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 26,279,1982

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TYPE OF TEST            : TDLo - Lowest

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 550 mg/kg
SEX/DURATION            : female 6-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya.  Experimental and
   Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049
   Moscow, Russia)  V.55-    1992-  Volume(issue)/page/year: 56(4),37,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE                    : 10 ug/kg
SEX/DURATION            : female 9 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 19,29,1979

TYPE OF TEST            : TDLo - Lowes

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs & Metabolites - Forensic and Veterinary Standards
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Lipids - Biochemicals and Reagents
  4. Fatty Acyls - Lipids
  5. Eicosanoids (Prostaglandins, Leukotrienes) - Fatty Acyls
  6. Prostaglandins - Eicosanoids (Prostaglandins, Leukotrienes)
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Prostaglandin Receptor  (前列腺素受体)

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