IRL-1620
CAS 142569-99-1 MFCD00214284
化学结构图
SMILES: C[C@@H](CC)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](C)NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CCC(O)=O)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2C=CC=CC1=2)C(O)=O
化学属性
| Mol. Formula | C86H117N17O27 |
|---|---|
| Mol. Weight | 1820.95 |
别名和识别编码
| Chemical Name | IRL-1620 |
|---|---|
| Synonym | IRL-1620 N-Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp N-Succinyl-[Glu9, Ala11,15]-Endothelin 1 fragment 8-21 |
| MDL Number | MFCD00214284 |
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分类
- {SNA} Agonists, Cell Biology, Cell Signaling and Neuroscience, Endothelins, Peptides and Proteins, Peptides for Cell Biology
相关文献及参考
- [2]. Briyal S, et al. Stimulation of endothelin B receptors by IRL-1620 decreases the progression of Alzheimer's disease. Neuroscience. 2015 Aug 20;301:1-11.
- [3]. Gulati S, et al. Attenuation of opioid tolerance by ETB receptor agonist, IRL-1620, is independent of an accompanied decrease in nerve growth factor in mice. Heliyon. 2017 Jun 7;3(6):e00317.
- [1]. Takai M, et al. A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor. Biochem Biophys Res Commun. 1992 Apr 30;184(2):953-9.
- [1]. Takai M, et al. A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor. Biochem Biophys Res Commun. 1992 Apr 30;184(2):953-9.
- [2]. Briyal S, et al. Stimulation of endothelin B receptors by IRL-1620 decreases the progression of Alzheimer's disease. Neuroscience. 2015 Aug 20;301:1-11.
- [3]. Gulati S, et al. Attenuation of opioid tolerance by ETB receptor agonist, IR
