CAS 16837-52-8 MFCD00210339-Ammothamnine 氧化苦参碱 TAO{mole}

Ammothamnine 氧化苦参碱

CAS 16837-52-8 MFCD00210339

化学结构图

SMILES: [O-][N+]12CCC[C@H]3CN4[C@H](CCCC4=O)[C@@H](CCC1)[C@@H]23

化学属性

Mol. Formula	C15H24N2O2
Mol. Weight	264
Melting Point	199-201

别名和识别编码

Chemical Name	Ammothamnine
Synonym	(1β)-Matridin-15-one 1-oxide, Matrine 1-oxide, Matrine N-oxideM, (+)-matrine N-oxide, (+)-Oxymatrine Matridin-15-one, 1-oxide, (1-beta)- Matrine N-oxide Oxymatrine Oxymatrine; Matrine N-oxide
CAS Number	16837-52-8
MDL Number	MFCD00210339
Chemical Name Translation	氧化苦参碱

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安全信息

Hazard Codes Xn

GHS Symbol

Hazard statements

H302 Harmful if swallowed 吞食有害

WGK Germany3

Signal word Warning

RTECSOQ1770000

Risk Statements

R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
R22 Harmful if swallowed 吞咽有害

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 18,2555,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 257 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China
   International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24-
   1989-  Volume(issue)/page/year: 27,201,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 521 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book
   Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23,    1978-88. For
   publisher information, see ZYZAEU.  Volume(issue)/page/year: 18(7),23,1983

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Precautionary statements

P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。