CAS 2614-06-4 MFCD00210220-(R)-(+)-Thalidomide (R)-(+)-沙利度胺 TAO{mole}

(R)-(+)-Thalidomide (R)-(+)-沙利度胺

CAS 2614-06-4 MFCD00210220

化学结构图

SMILES: O=C1CC[C@@H](N2C(=O)c3ccccc3C2=O)C(=O)N1

化学属性

Mol. Formula	C13H10N2O4
Mol. Weight	258.25

别名和识别编码

Chemical Name	(R)-(+)-Thalidomide
CAS Number	2614-06-4
Synonym	R-(+)-Thalidomide (+)-Thalidomide (R)-Thalidomide 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-, (R)- NSC 91729 (R)-(+)-2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione
MDL Number	MFCD00210220
PubChem Substance ID	75792
Chemical Name Translation	(R)-(+)-沙利度胺
InChIKey	UEJJHQNACJXSKW-SECBINFHSA-N
Wiswesser Line Notation	T56 BVNVJ C- DT6VMVTJ
InChI	InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)/t9-/m1/s1

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分类

Chiral Reagents
Pharmaceuticals
Intermediates & Fine Chemicals,
{SNA} Angiogenesis Regulators, Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Celgene, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, ECM Related Proteins and Peptides, Enzymes, Inhibitors, and Substrates, Extracellular Matrix, Matrix Metalloproteinases Products, T

产品应用

Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative.

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
H302 Harmful if swallowed 吞食有害

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RTECSTI4925000

Precautionary statements

P308+P313
P201 Obtain special instructions before use. 使用前获取专门指示。

Signal word Danger

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Hazard Codes T

Risk Statements

R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
R22 Harmful if swallowed 吞咽有害

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 215,296,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 29,1640,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 900 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 215,296,1967