CAS 2259-96-3 MFCD00210192-6-Chloro-3,4-Dihydro-3-(2-Norbornen-5-Yl)-2H-1,2-4-Benzothiadiazine-7-Sulfonamide 1,1-Dioxide 6-氯-3,4-二氢-3-(2-降冰片烯-5-基)-2H-1,2-4-苯并噻二嗪-7-磺酰胺1,1-二氧化物 TAO{mole}

6-Chloro-3,4-Dihydro-3-(2-Norbornen-5-Yl)-2H-1,2-4-Benzothiadiazine-7-Sulfonamide 1,1-Dioxide 6-氯-3,4-二氢-3-(2-降冰片烯-5-基)-2H-1,2-4-苯并噻二嗪-7-磺酰胺1,1-二氧化物

CAS 2259-96-3 MFCD00210192

化学结构图

SMILES: NS(=O)(=O)c1cc2c(cc1Cl)NC(C1CC3C=CC1C3)NS2(=O)=O

化学属性

Mol. Formula	C14 H16 Cl N3 O4 S2
Mol. Weight	389.88

别名和识别编码

Chemical Name	6-Chloro-3,4-Dihydro-3-(2-Norbornen-5-Yl)-2H-1,2-4-Benzothiadiazine-7-Sulfonamide 1,1-Dioxide
CAS Number	2259-96-3
Synonym	######## 6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2-4-benzothiadiazine-7-sulfonamide 1,1-dioxide Anhydron Aquirel Cyclothiazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL Number	MFCD00210192
PubChem Substance ID	2910
EC Number	218-859-7
Chemical Name Translation	6-氯-3,4-二氢-3-(2-降冰片烯-5-基)-2H-1,2-4-苯并噻二嗪-7-磺酰胺1,1-二氧化物
Wiswesser Line Notation	T66 BSWM EM DHJ HG ISZW D- FL55 A CUTJ
Beilstein Registry Number	0722843
Reaxys-RN	722843
Merck Number	2754
InChI	InChI=1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20)
Canonical SMILES	O=S(C1=C(Cl)C=C(C2=C1)NC(C3C(C4)C=CC4C3)NS2(=O)=O)(N)=O

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分类

{SNA} AMPA/Kainate Other, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, CI-CY, Cell Signaling and Neuroscience, Eli Lilly, Excitatory Amino Acids, Ion Channels, Ionotropic Glutamate Receptor Modulators, Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Neurotransmitters, 细胞生物学
{SNA} AMPA/Kainate Other, Approved Therapeutics/Drug Candidates, CI-CY, Eli Lilly, Excitatory Amino Acids, Ion Channels, Ionotropic Glutamate Receptor Modulators, Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Neur

产品应用

Diuretic; antihypertensive. A subunit-specific inhibitor of GABAC receptors

安全信息

WGK Germany2

GHS Symbol

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

RTECSDK9610000

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xi

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   101,929,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   101,929,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,460,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 18,487,1968

Storage condition +4°C 0-10°C 2-8°C 2-8°C, protect from light 4℃