5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(1-piperazinyl)- 8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]二氮杂卓
CAS 6104-71-8 MFCD00210189
化学结构图
SMILES: Clc1ccc2c(c1)N=C(N1CCNCC1)c1ccccc1N2
化学属性
| Mol. Formula | C17H17ClN4 |
|---|---|
| Mol. Weight | 313 |
| Melting Point | 120-125°C |
别名和识别编码
| Chemical Name | 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(1-piperazinyl)- |
|---|---|
| CAS Number | 6104-71-8 |
| Synonym | 8-Chloro-11-(1-piperazinyl)-5H-dibenzo[B,E][1,4]diazepine 8-Chloro-11-piperazinyl-5H-dibenzo[b,e][1,4]diazepine Norclozapine Normethylclozapine 8-chloro-11-piperazin-1-yl-5H-dibenzo(B,E)(1,4)diazepine N-DESMETHYLCLOZAPINE N-Desmethylclozapine N-desmethylclozapine desmethylclozapine norclozapine |
| MDL Number | MFCD00210189 |
| PubChem Substance ID | 135409468 |
| Chemical Name Translation | 8-氯-11-(1-哌嗪基)-5H-二苯并[B,E] [1,4]二氮杂卓 |
| LabNetwork Molecule ID | LN01271441 |
| InChI | InChI=1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2 |
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分类
- {SNA} Antagonists, Bioactive Small Molecule Alphabetical Index, D-DIF, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Serotonergics, Serotonergics - Antagonists, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
- Pharmaceuticals
- {SNA}
- {SNA} Antagonists, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D-DIF, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools,
- {
产品应用
- A major metabolite of Clozapine (C587500). A potent and selective 5-HT2C serotonin receptor antogonist.
相关文献及参考
- [2]. Odagaki Y, et al. Comparative analysis of pharmacological properties of xanomeline and N-desmethylclozapine in rat brain membranes. J Psychopharmacol. 2016 Sep;30(9):896-912
- [3]. Sugawara Y, et al. Electrophysiological evidence showing muscarinic agonist-antagonist activities of N-desmethylclozapine using hippocampal excitatory and inhibitory neurons. Brain Res. 2016 Jul 1;1642:255-62
- [4]. Gigout S, et al. Different pharmacology of N-desmethylclozapine at human and rat M2 and M 4 mAChRs in neocortex. Naunyn Schmiedebergs Arch Pharmacol. 2015 May;388(5):487-96
- [5]. Himmerich H, et al. Impact of clozapine, N-desmethylclozapine and chlorpromazine on thromboxane production in vitro. Med Chem. 2012 Nov;8(6):1032-8.
- [6]. Medigeshi GR, et al. N-Desmethylclozapine, Fluoxetine and Salmeterol inhibit post-entry stages of dengue virus life-cycle. Antimicrob Agents Chemother. 2016 Aug 29.
- Kuoppamaki, M. et al.: Eur. J. Pharm. Mol. Pharm.
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312
- P302+P352
- P304+P312
- P304+P340
- P305+P351+P338
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P330 Rinse mouth. 漱口
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H302 Harmful if swallowed 吞食有害
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H332 Harmful if inhaled 吸入有害
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S22 Do not breathe dust 不要吸入粉尘；
- R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
其他信息
- Sigma Aldrich:6104-71-8(sigmaaldrich)
- MOL 文件:6104-71-8.mol
