MY-5445 1-(3-氯苯胺基)-4-苯基酞嗪
CAS 78351-75-4 MFCD00209838
化学结构图
SMILES: ClC1=CC(=CC=C1)NC1N=NC(=C2C=CC=CC2=1)C1C=CC=CC=1
化学属性
| Mol. Formula | C20H14ClN3 |
|---|---|
| Mol. Weight | 331.80 |
别名和识别编码
| Chemical Name | MY-5445 |
|---|---|
| Synonym | MY-5445 |
| MDL Number | MFCD00209838 |
| Chemical Name Translation | 1-(3-氯苯胺基)-4-苯基酞嗪 |
| PubChem Substance ID | 253661527 |
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相关文献及参考
- [2]. Chung-Pu Wu, et al. MY-5445, a phosphodiesterase type 5 inhibitor, resensitizes ABCG2-overexpressing multidrug-resistant cancer cells to cytotoxic anticancer drugs. Am J Cancer Res. 2020; 10(1): 164-178.
- [3]. Maud Bollenbach, et al. Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model. Eur J Med Chem. 2019 Sep 1;177:269-290.
- [1]. Souness JE, et al. Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine. Br J Pharmacol. 1989 Nov;98(3):725-34.
- [1]. Souness JE, et al. Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine. Br J Pharmacol. 1989 Nov;98(3):725-34.
- [2]. Chung-Pu Wu, et al. MY-5445, a phosphodiest
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
