Quinine 奎宁
CAS 130-95-0 MFCD00198096
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Alphabetical, Analytical Standards, Certified Reference Materials (CRMs), Chromatography, Cinchona, Fluka CRMs for Chromatography (neats), Life Sciences Standards, N - R, Natural Products, Nitrogen containing compounds, Organic CRMs Alphabetical, Organic CRMs TraceCERT, Phytopharma Standards, Standards by Plant Genus, Substance Classification, 分析/色谱
- {SNA} Alkaloid, Asymmetric Synthesis, Chemical Synthesis, Chiral Catalysts, Ligands, and Reagents, Chiral Resolution Reagents, Chiral Resolving Reagents, Cinchona Alkaloids, Ion Channels,
- {SNA} Alkaloid,
产品应用
- 钾离子通道阻断剂。手性催化剂,用于高异构体选择性[2+2]环加成反应;二乙基锌添加到醛上。
相关文献及参考
- Resolving agent for chiral acids. For a review of resolutions, see: Topics Stereochem., 6, 107 (1977).
- Merck: 14,8061
- Merck: 14,8061 Beilstein:23(2)416
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P301+P312+P330
- P302+P350
- P302+P352+P333+P313+P362+P364
- P305+P351+P338
- P337+P313
- P342+P311
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H315 Causes skin irritation 会刺激皮肤
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H319 Causes serious eye irritation 严重刺激眼睛
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
- H302 Harmful if swallowed 吞食有害
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S22 Do not breathe dust 不要吸入粉尘;
- S24 Avoid contact with skin 避免皮肤接触;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- S37 Wear suitable gloves 戴适当手套;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- R22 Harmful if swallowed 吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
- R42/43
TYPE OF TEST : LDLo - Lowest publi
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 74 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Ear) - tinnitus Gastrointestinal - nausea or vomiting REFERENCE : AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 90,403,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 115 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
{
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 68 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 4,105,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 1800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/
TYPE OF TEST : DNA adduct TEST SYSTEM : Mammal - species unspecified Lymphocyte DOSE/DURATION : 100 umol/L REFERENCE : PMSBA4 Progress in Molecular and Subcellular Biology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1969- Volume(issue)/page/year: 2,134,1971
TYPE OF TEST : DNA adduct TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 30 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE : 650 mg/kg SEX/DURATION : female 4-8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : ARPTAF Arkhiv Patologii. Archives of Pathology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.8- 1946- Volume(issue)/page/year: 20(12),64,1958
TYPE OF TEST : TDLo - Lowest publi
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE : 280 mg/kg SEX/DURATION : female 7-8 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System REFERENCE : ARPTAF Arkhiv Patologii. Archives of Pathology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.8- 1946- Volume(issue)/page/year: 20(12),64,1958
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSU
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE : 60 mg/kg SEX/DURATION : female 7 week(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - hepatobiliary system REFERENCE : ARKIAP Archiv fuer Kinderheilkunde. (Stuttgart, Fed
其他信息
- 比旋光度:-172 ° (c=1, EtOH)
- 下游产品:(S)-1,1-螺二氢茚-7
- Alfa Aesar:无水奎宁,99%(totalbase),maycont.upto5%dihydroquinine Quinine, anhydrous, 99% (total base), may cont. up to 5% dihydroquinine(130-95-0)
- www.aladdin-reagent.com奎宁是一种喹啉型生物碱。存在于茜草科金鸡纳树皮中。二盐酸奎宁的熔点180~185℃,易溶于水、乙醇;奎宁硫酸盐的熔点235.2℃。为金鸡纳树皮中存在的主要生物碱。白色颗粒状或微晶性粉末,微风化性。无臭,味微苦。微溶于水和甘油,易溶于乙醇,氯仿,溶于稀酸、稀氨水中。在硫酸中呈强蓝色荧光。与许多酸易生成盐。 熔点:173~177℃ 比旋光度:-145.2°(乙醇)
- 理化性质:奎宁又名金鸡纳霜、金鸡纳碱,是茜草科植物金鸡纳树及其同属植物的树皮中的主要生物碱,金鸡纳树皮含有20多种生物碱,除奎宁外,有抗疟作用的还有奎尼丁、辛可宁及辛可尼丁等。以金鸡纳树皮的全部生物碱作抗疟药和解热药,称金鸡纳全碱或全奎宁。奎宁化学上属喹啉类,与奎尼丁互为异构体。白色无定形粉末或结晶,无臭,味极苦。熔点172.8℃,有左旋光性,[α]D20-168°(乙醇) 。溶于乙醇、氯仿、苯、乙醚,微溶于水。其稀硫酸溶液有蓝色荧光,滴加溴水及过量氨水,即显翠绿色。将金鸡纳树皮粉以石灰与氢氧化钠处理,煤油提取,稀硫酸中和,将析出的硫酸奎宁与氨作用即得。也可以间羟基苯甲醛与α-氨基乙醛为原料合成。用于治疗和预防各种疟疾,药用为其硫酸盐或盐酸盐
- 用途二:钾离子通道阻断剂。手性催化剂,用于高异构体选择性[2+2]环加成反应;二乙基锌添加到醛上。
- 不良反应:1,金鸡纳反应:每日奎宁用量超过1g或稍久即可出现,表现为恶心、呕吐、耳鸣、头痛、视力听力减退,停药后一般可恢复。 2,特异质反应:可见急性溶血、皮炎、瘙痒、血管神经性水肿及支气管哮喘等。少数恶性疟患者小剂量奎宁可见寒战、高热、呕吐、血红蛋白尿、尿闭等急性溶血症,称黑尿热,严重者可致死。 3,静脉推注,可抑制心脏引起血压下降,甚至休克危及生命,故严禁静脉推注。静滴也应慎用。肌注易致组织坏死,除不能口服外,一般不用。
- 检测方法:HPLC,Rotation
- F:8
- 奎宁价格(试剂级):更新日期 产
- Sigma Aldrich:130-95-0(sigmaaldrich)
- 注意事项:1.大剂量易致第八对脑神经及视神经损害,耳聋、前庭障碍、视神经炎患者禁用。患有急性静脉炎、肾炎、糖尿病、心血管疾病、心动过缓、房室传导阻滞者禁用。大剂量可致畸和有兴奋子宫平滑肌作用. 经期妇女、孕妇禁用。可降低骨骼肌兴奋性,故重症肌无力者禁用。 2.有抑制心脏作用,静脉推注易致休克,不宜采用; 静滴宜密切观察血压变化; 肌注可引起组织坏死,宜采用深部臀肌注射。禁与奎尼丁、氯喹等同时并用,以免引起心脏骤停。
- 外观性质:白色颗粒状或微晶性粉末,微风化性。无臭,味微苦。微溶于水和甘油,易溶于乙
- 理化性质:奎宁又名金鸡纳霜、金鸡纳碱,是茜草科植物金鸡纳树及其同属植物的树皮中的主要生物碱,金鸡纳树皮含有20多种生物碱,除奎宁外,有抗疟作用的还有奎尼丁、辛可宁及辛可尼丁等。以金鸡纳树皮的全部生物碱作抗疟药和解热药,称金鸡纳全碱或全奎宁。奎宁化学上属喹啉类,与奎尼丁互为异构体。白
- 奎宁价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 61004083 奎宁;金鸡纳碱;规宁;鸡钠碱;金鸡纳霜 10g 175元 2011/08/23 xw020107 奎宁;金鸡纳碱;规宁;鸡钠碱;金鸡纳霜 10g 150元 2011/08/23 6
- Quinine is a primary alkaloid of various species of Cinchona, optical isomer of Quinidine and an anti-malarial, skeletal, muscle relaxant.
- {Chemi