4-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo [2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methoxy]-1-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo [2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methoxy]phthalazine 氢化奎宁 1,4-(2,3-二氮杂萘)二醚

CAS 140924-50-1 MFCD00191975

化学结构图

140924-50-1
SMILES: CC[C@@H]1CN2CC[C@@H]1C[C@@H]2[C@H](Oc1nnc(O[C@H](c2ccnc3ccc(OC)cc23)[C@H]2C[C@@H]3CCN2C[C@@H]3CC)c2ccccc12)c1ccnc2ccc(OC)cc12

化学属性

Mol. FormulaC48H54N6O4
Mol. Weight778.98
Melting Point178 °C
Density1.3

别名和识别编码

Chemical Name4-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo [2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methoxy]-1-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo [2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methoxy]phthalazine
MDL NumberMFCD00191975
Beilstein Registry Number5475677
Synonym (DHQ)2PHAL AD-mix-alpha
PubChem Substance ID329755835
Chemical Name Translation氢化奎宁 1,4-(2,3-二氮杂萘)二醚
CAS Number140924-50-1
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分类

  • {SNA} Asymmetric Synthesis, Chemical Reagents, Chemical Synthesis, Chiral Catalysts, Ligands, and Reagents, Cinchona Alkaloids, Development Quantities for Research, Dihydroxylation, Privileged Ligands and Complexes
  • {SNA} Asymmetric Synthesis, Chemical Synthesis, Chiral Catalysts, Ligands, and Reagents, Cinchona Alkaloids, Dihydroxylation, Privileged Ligands and Complexes
  • Asymmetric Synthesis, Chemical Synthesis, Chiral Catalysts, Ligands, and Reagents, Cinchona Alkaloids, Dihydroxylation, Privileged Ligands and Complexes

产品应用

  • 配体，用于不饱和酯和三取代 C=C 键的非对称二羟基化。

相关文献及参考

  • 1. J. Org. Chem. 71 , 7741, (2006) 摘要
  • 2. Eur. J. Org. Chem. , 2669, (2006)
  • J. Org. Chem. 57 , 2768, (1992)
  • Aldrichimica Acta 27 , 70, (1994)
  • Chem. Rev. 94 , 2483, (1994)

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard Codes Xn
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
Signal word Warning
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R32 Contact with acids liberates very toxic gas 与酸接触释放出毒性很高的气体
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害

系列性分类

  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Catalysts, Ligands, and Reagents - Asymmetric Synthesis
  4. Dihydroxylation - Chiral Catalysts, Ligands, and Reagents
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Catalysts, Ligands, and Reagents - Asymmetric Synthesis
  4. Privileged Ligands and Complexes - Chiral Catalysts, Ligands, and Reagents
  5. Cinchona Alkaloids - Privileged Ligands and Complexes
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Catalysts, Ligands, and Reagents - Asymmetric Synthesis
  4. Privileged Ligands and Complexes - Chiral Catalysts, Ligands, and Reagents
  5. Cinchona Alkaloids - Privileged Ligands and Complexes
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Catalysts, Ligands, and Reagents - Asymmetric Synthesis
  4. Chiral Ligands

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