CAS 2624-43-3 MFCD00190153-Cyclofenil 环芬尼 TAO{mole}

Cyclofenil 环芬尼

CAS 2624-43-3 MFCD00190153

化学结构图

SMILES: CC(=O)Oc1ccc(C(=C2CCCCC2)c2ccc(OC(C)=O)cc2)cc1

化学属性

Mol. Formula	C23H24O4
Mol. Weight	364.47
Appearance	solid
Solubility	Soluble in DMSO: ≥10 mg/mL,

别名和识别编码

Chemical Name	Cyclofenil
CAS Number	2624-43-3
Synonym	######## (Cyclohexylidenemethanediyl)dibenzene-4,1-diyl diacetate 4,4′-Cyclohexylidenemethylenediphenol 4,4'-CYCLOHEXYLIDENEMETHYLENEDIPHENOL DIACETATE 4-((4-(Acetyloxy)phenyl)cyclohexylidenemethyl)phenol Acetate 4-((4-(acetyloxy)phenyl)cyclohexylidenemethyl)-phenoacetate 4-(CYCLOHEXYLIDENEMETHYLENE)-BIS-PHENOL DIACETATE 4-(Cyclohexylidenemethylene)-bis-phenol Bis-(p-acetoxyphenyl)-cyclohexylidenemethane Bis-(p-hydroxyphenyl)-cyclohexylidenemethane diacetate CYCLOFENIL Cyclofenil Cyclofenyl Cyclopenil Cyclophenil Cyclophenyl F 6066 F-6066 F6066 Fertodur; (Cyclohexylidenemethanediyl)dibenzene-4,1-diyl diacetate; [4-[(4-Acetyloxyphenyl)-cyclohexylidenemethyl]phenyl] acetate H 3452 ICI 48213 Oginex
MDL Number	MFCD00190153
EC Number	220-089-1
Chemical Name Translation	环芬尼
Wiswesser Line Notation	L6YTJ AUYR DQ&R DQ
Beilstein Registry Number	2014687
LabNetwork Molecule ID	LN00202493
PubChem Substance ID	2898
InChI	InChI=1S/C23H24O4/c1-16(24)26-21-12-8-19(9-13-21)23(18-6-4-3-5-7-18)20-10-14-22(15-11-20)27-17(2)25/h8-15H,3-7H2,1-2H3

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产品应用

A selective estrogen receptor modulator

安全信息

WGK Germany2

RTECSGO7550000

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Storage condition 储存温度2-8℃ 2-8°C

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >12 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,313,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >12500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - anorexia (human)
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   23,365,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >12 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,313,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1080 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - hair
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 4,821,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : female 3 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   BIREBV Biology of Reproduction.  (Soc. for the Study of Reproduction, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1969-  Volume(issue)/page/year:
   1,397,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 32 mg/kg
SEX/DURATION            : female 1-2 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   25,65,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 32 mg/kg
SEX/DURATION            : female 3-4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   25,65,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 20 mg/kg
SEX/DURATION            : female 3-4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   APTSAI Acta Pharmacologica et Toxicologica, Supplementun.  (M

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P302+P352
P305+P351+P338
P308+P313
P318
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P332+P313
P332+P317
P337+P313
P337+P317
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

其他信息

MSDS 信息:[4-[(4-Acetyloxyphenyl)-cyclohexylidenemethyl]phenyl] acetate(2624-43-3).msds
Cyclofenil is a non-steroidal selective estrogen receptor modulator (SERM). Cyclofenil shows a higher affinity for ERβ than ERα.
MOL 文件:2624-43-3.mol
Sigma Aldrich:2624-43-3(sigmaaldrich)