Olomoucine is a CDK inhibitor that competes for the ATP binding site of the kinase. Olomoucine was shown to reversibly arrest differentiated Petunia cells induced to divide at G1 phase and cycling Arabidopsis cells in late G1 and G2. 2-(2'-羟基乙基氨基)-9-甲基-6-(苄基氨基)嘌呤
CAS 101622-51-9 MFCD00189360
化学结构图
SMILES: Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc21
化学属性
| Mol. Formula | C15H18N6O |
|---|---|
| Mol. Weight | 298.34 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | Olomoucine is a CDK inhibitor that competes for the ATP binding site of the kinase. Olomoucine was shown to reversibly arrest differentiated Petunia cells induced to divide at G1 phase and cycling Arabidopsis cells in late G1 and G2. |
|---|---|
| CAS Number | 101622-51-9 |
| Synonym | 2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine N2-[(2-Hydroxyethyl)-N6-benzyladenine NSC 666096 Olomoucine |
| MDL Number | MFCD00189360 |
| PubChem Substance ID | 24278053 |
| Chemical Name Translation | 2-(2'-羟基乙基氨基)-9-甲基-6-(苄基氨基)嘌呤 |
| Formula | C15H18N6O |
| IUPAC Name | 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine |
| InChIKey | GTVPOLSIJWJJNY-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20) |
| Canonical SMILES | CN1C=NC2=C(NCC3=CC=CC=C3)N=C(NCCO)N=C12 |
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分类
- Bases & Related Reagents
- {SNA} A to C, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cyclin Dependent Kinases, Cyclin-Dependent Kinase (CDK), Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Kinase/Phosphatase Biology, O,
产品应用
- Olomoucine is a CDK inhibitor that competes for the ATP binding site of the kinase. Olomoucine was shown to reversibly arrest differentiated Petunia cells induced to divide at G1 phase and cycling Arabidopsis cells in late G1 and G2.
相关文献及参考
- Vesely, J., et a.: Eur. J. Biochem., 224, 771 (1994),
- Vesely, J., et al., Inhibition of cyclin-dependent kinases by purine analogues. Eur. J. Biochem. 224 , 771-786, (1994) 摘要
- Abraham, R.T., et al., Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol. Cell 83 , 105-120, (1995) 摘要
