Apamin 蜂毒明肽
CAS 24345-16-2 MFCD00167944
化学结构图
SMILES: CC(C)C[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CSSC[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N2)NC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(N)=O)[C@@H](C)O
化学属性
| Mol. Formula | C79H131N31O24S4 |
|---|---|
| Mol. Weight | 2027.34 |
| Density | 1.63 |
别名和识别编码
| Chemical Name | Apamin |
|---|---|
| MDL Number | MFCD00167944 |
| PubChem Substance ID | 24891455 |
| CAS Number | 24345-16-2 |
| EC Number | 246-182-7 |
| Synonym | Apamine Apamine; L-Cysteinyl-L-asparaginyl-L-cysteinyl-L-lysyl-L-alanyl-L-prolyl-L-alpha-glutamyl-L-threonyl-L-alanyl-L-leucyl-L-cysteinyl-L-alanyl-L-arginyl-L-arginyl-L-cysteinyl-L-glutaminyl-L-glutaminyl-L-histidinamide cyclic (1-11) (3-15)-bis(disulfide) = Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-leu-Cyc-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 |
| Chemical Name Translation | 蜂毒明肽 |
| LabNetwork Molecule ID | LN02124820 |
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分类
- AN-AZ, Bee, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channel Modulating Peptides, Ion Channels, Monovalent Ion Channels, Peptides and Proteins, Peptides for Cell Biology, Potassium Channel Modulators, Toxins and Venoms, Voltage-gated Ion Channels
- {SA} AN-AZ, Bee,
- {SNA} Bee, Ion Channel Modulating Peptides, Ion Channels, Monovalent Ion Channels, Peptides and Proteins, Peptides for Cell Biology, Potassium Channel Modulators, Toxins and Venoms, Voltage-gated Ion Channels, 细胞信号转导和神经科学,
- {SNA} Bee,
相关文献及参考
- van der Staay, F.J., et al., Behavioral effects of apamin, a selective inhibitor of the SK(Ca)-channel, in mice and rats. Neurosci. Biobehav. Rev. 23 , 1087-1110, (1999)
- Tanabe, M., et al., Apamin-sensitive conductance mediates the K(+) current response during chemical ischemia in CA3 pyramidal cells. J. Neurophysiol. 82 , 2876-2882, (1999)
- Butcher, J.W., et al., Differential effects of apamin on neuronal excitability in the nucleus tractus solitarii of rats studied in vitro. . J. Auton. Nerv. Syst. 77 , 90-97, (1999) 摘要
- Merck 14 ,725
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,157,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 22,308,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2900 ug/kg TOXIC EFFECTS : Behavioral - ataxia REFERENCE : EJBCAI European Journal of Biochemistry. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1967- Volume(issue)/page/year: 56,35,1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intracerebral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1800 ng/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 22,308,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4 mg/kg TOXIC EFFECTS : Behavioral - excitement Beha
- P342+P311
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
GHS Symbol
