DESLORELIN
CAS 57773-65-6 MFCD00167401
化学结构图
SMILES: CC(C)C[C@H](NC(=O)[C@@H](CC1=CNC2C=CC=CC=21)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CNC2C=CC=CC=21)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC
化学属性
| Mol. Formula | C64H83N17O12 |
|---|---|
| Mol. Weight | 1282.45 |
别名和识别编码
| Chemical Name | [des-Gly10, D-Trp6]-LH-RH ethylamide |
|---|---|
| Synonym | Bachem 9022 (D-Trp(sup 6)-pro(sup 9))-luteinizing hormone-releasing hormone Deslorelin D-Trp(sup 6)-pro(sup 9)-N-ethylamide-LHRH Somagard Gonadotropin releasing hormone, (D-trp(sup 6)-pro(sup 9)-NEt)- (D-Trp(sup 6)-pro(sup 9))-LHRH ethylamide (D-Trp(sub 6)-pro(sup 9)-NEt)-GNRH |
| MDL Number | MFCD00167401 |
| CAS Number | 57773-65-6 |
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分类
- Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, L, LH-RH, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Releasing Factors
- {SNA} LH-RH, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Releasing Factors, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, L, LH-RH, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Releasing Factors
相关文献及参考
- Krsmanovic, L.Z., et al., Autocrine regulation of gonadotropin-releasing hormone secretion in cultured hypothalamic neurons. Endocrinology 140 , 1423-1431, (1999) 摘要
- Naqvi, R.H., and Lindberg, M.C., Biopharmaceutic stability of [D-Trp 6 , des-Gly 10 ]-LHRH ethyl amide in corn oil. Endocrinol. Res. 11 , 139-144, (1985)
- Merck 14 ,2923
安全信息
GHS Symbol
- P308+P313
- P201 Obtain special instructions before use. 使用前获取专门指示。
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
TYPE OF TEST : TDLo - Low
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Human - man DOSE : 30 ug/kg SEX/DURATION : male 42 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - sperm
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Primate - monkey DOSE : 150 ug/kg SEX/DURATION : female 75 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders REFERENCE : INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 25,171,1980
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 28 ng/kg SEX/DURATION : male 7 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 105,1191,1979
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 15 ug/kg SEX/DURATION : female 5-7 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - live birth index (measured after birth) REFERENCE : ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 103,2299,1978
TYPE OF TEST
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S22 Do not breathe dust 不要吸入粉尘；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- R60 May impair fertility 可能降低生殖能力
