Angiotensin Ⅱ 血管紧张素II
CAS 4474-91-3 MFCD00161484
化学结构图
SMILES: CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
化学属性
| Mol. Formula | C50H71N13O12 |
|---|---|
| Mol. Weight | 1046.34 |
| Density | 1.43 |
| Solubility | Soluble in Water (25 mg/ml), and 5% Acetic Acid (1 mg/ml). |
| Stability | 热敏感 |
别名和识别编码
| Chemical Name | Angiotensin Ⅱ |
|---|---|
| MDL Number | MFCD00161484 |
| Synonym | 5 L Isoleucine Angiotensin II 5-L-Isoleucine Angiotensin II 5-L-Isoleucineangiotensin II ANG-(1-8)Octapeptide Angiotensin II Angiotensin II (mouse) Angiotensin II, 5-L-Isoleucine Angiotensin II, Ile(5)- Angiotensin II, Isoleucine(5)- Angiotensin II, Val(5)- Angiotensin II, Valine(5)- Angiotensin II, human Angiotensin II, mass spec standard Angiotensin-(1-8) Octapeptide Human angiotensin II Isoleucine(5)-Angiotensin Isoleucyl(5)-Angiotensin II ProteoMass™ Angiotensin II MALDI-MS Standard Valyl(5)-Angiotensin II 人血管紧张素 II 人血管紧张素II相对分子质量标准物质 |
| Chemical Name Translation | 血管紧张素II |
| PubChem Substance ID | 172198 |
| CAS Number | 4474-91-3 |
| LabNetwork Molecule ID | LN00200056 |
| InChI | InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1 |
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分类
- {SNA} Angiotensins, Application Index, Cell Signaling Enzymes, Chymase and Related Products, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Mass Spectrometry, P, PON - PT, Peptide and protein standards for mass spectrometry analysis, Proteomics
- {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, Mass Spectrometry, P, PON - PT, Peptide and
产品应用
- 校准仪器和装置；评价方法；工作标准；质量保证/质量控制
相关文献及参考
- [2]. Fyhrquist F, et al. Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders. J Hum Hypertens. 1995 Nov;9 Suppl 5:S19-24.
- [3]. Crowley SD, et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17985-90.
- [1]. de Gasparo M, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep;52(3):415-72.
- [1]. de Gasparo M, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep;52(3):415-72.
- [2]. Fyhrquist F, et al. Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders. J Hum Hypertens. 1995 Nov;9 Suppl 5:S19-24.
- [3]. Crowley SD, et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 17400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,6079,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 30800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,6079,1990
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 119 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,6109,1990
其他信息
- 标准值 扩展不确定度（k=2） 单位 人血管紧张素II 1045.5 1.2 标准值
- 标准值 扩展不确定度（k=2） 单位
- Angiotensin II plays an important role in the regulation of blood pressure and has strong vasoconstrictive effects. It also stimulates the release of aldosterone from the adrenal gland and inhibits adenylate cyclase activity in spontaneously hypertensive rats. Angiotensin II increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase (MYLK). It also elicits an increase in voltage-dependent delayed rectifier K+ current in neurons and activates JAK2 in smooth muscle cells. Furthermore, angiotensin II activates FAK (p125FAK) and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. It also activates c-Src (p60c-src), ERK1/2, JNK, and p38α (p38 MAP Kinase) in vascular smooth muscle cells.
