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分类

• Inhibitors; Nitric Oxide Reagents
• {KO} Nitros
• {KO} ReacBromides
• {KO} AminesSecondaryHeteroNH
• {SA} Application Index, B, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, L to O, NOS Inhibitors, Nitric Oxide Metabolism, Nitric Oxide Synthase (iNOS), Nitric Oxide Synthase Regulators, Nitric Oxide Synthase neuronal, Nitric Oxide and Cell Stress

产品应用

• A more potent inhibitor of rat cerebellar nitric oxide synthase than 7-nitroindazole.

相关文献及参考

• Bland-Ward, et al.: Br. J. Pharm., 112, 351P (1994)
• 1. Raman, C.S., et al., Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism Biochemistry 40 , 13448-13455, (2001) 摘要
• Bland-Ward, P.A., and Moore, P.K., 7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase. Life Sci. 57 , PL131-PL135, (1995) 摘要
• Wada, K., et al., Role of nitric oxide in traumatic brain injury in the rat. J. Neurosurg. 89 , 807-818, (1998) 摘要
• O'Neill, M.J., et al., Neuroprotective effects of the antioxidant LY231617 and NO synthase inhibitors in global cerebral ischaemia. Brain Res. Brain Res. 760 , 170-178, (1997) 摘要
• Stagliano, N.E., et al., The role of nitric oxide in the pathophysiology of thromboembolic stroke in the rat. Brain Res. 759 , 32-40, (1997) 摘要

安全信息

药物吸收、分布、代谢与排泄(ADME)