Etanidazole (SR-2508) is a 2-nitroimidazole drug with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the cytotoxicity of ionizing radiation. This agent may also be useful as an imaging agent for identifying hypoxic, drug-resistant regions of primary tumors or metastases. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
CAS 22668-01-5 MFCD00156108
化学结构图
SMILES: O=C(Cn1ccnc1[N+](=O)[O-])NCCO
化学属性
| Mol. Formula | C7H10N4O4 |
|---|---|
| Mol. Weight | 214 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | Etanidazole (SR-2508) is a 2-nitroimidazole drug with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the cytotoxicity of ionizing radiation. This agent may also be useful as an imaging agent for identifying hypoxic, drug-resistant regions of primary tumors or metastases. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). |
|---|---|
| Synonym | 1H-Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro- Etanidazole; SR2508; SR 2508; SR-2508 N-(2-Hydroxyethyl)-1-(2-nitro-1-imidazolyl)acetamide N-(2-Hydroxyethyl)-2-nitro-1H-imidazole-1-acetamide NSC 301467 SR 2508 |
| MDL Number | MFCD00156108 |
| PubChem Substance ID | 24894494 |
| CAS Number | 22668-01-5 |
| Wiswesser Line Notation | T5N CNJ A1VM2Q BNW |
| Beilstein Registry Number | 0919296 |
| Chemical Name Translation | |
| Formula | C7H10N4O4 |
| IUPAC Name | N-(2-Hydroxyethyl)-2-(2-nitro-1H-imidazol-1-yl)acetamide |
| InChIKey | WCDWBPCFGJXFJZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C7H10N4O4/c12-4-2-8-6(13)5-10-3-1-9-7(10)11(14)15/h1,3,12H,2,4-5H2,(H,8,13) |
| Canonical SMILES | O=C(NCCO)CN1C=CN=C1[N+]([O-])=O |
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分类
- {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, E, EQ - EZ, Forensic and Veterinary Standards, Neat Compounds, Others
产品应用
- Etanidazole (SR-2508) is a 2-nitroimidazole drug with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the cytotoxicity of ionizing radiation. This agent may also be useful as an imaging agent for identifying hypoxic, drug-resistant regions of primary tumors or metastases. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RAREAE Radiation Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1954- Volume(issue)/page/year: 91,186,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3716 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Musculoskeletal - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases REFERENCE : TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,153,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4900 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4371540
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 80,113,1989
TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - mouse Embryo DOSE/DURATION : 1 mmol/L/3D (Continuous) REFERENCE : 45OJAG "Radiation Sensitizers: Their Use in the Clinical Management of Cancer, Proceedings of the Conference, Key Biscayne, FL, 1979," Brady, L.W., ed., New York, Masson Pub. USA, Inc., 1980 Volume(issue)/page/year: -,146,1980
