Arachidonylethanolamide 花生四烯酰乙醇胺
CAS 94421-68-8 MFCD00153766
化学结构图
SMILES: CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCO
化学属性
| Mol. Formula | C22H37NO2 |
|---|---|
| Mol. Weight | 347.53 |
| Density | 0.92 g/mL at 25 °C(lit.) |
别名和识别编码
| Chemical Name | Arachidonylethanolamide |
|---|---|
| Synonym | 5,8,11,14-Eicosatetraenoylethanolamide Arachidonylethanolamide 花生四烯酸乙醇胺 AEA Anandamide (20:4, n-6) 大麻素 花生四烯酸 N-(羟乙基)酰胺 大麻素 Anandamide N-Arachidonoyl-2-hydroxyethylamide AEA 大麻素 花生四烯酸 N-(羟乙基)酰胺 Anandamide (20.4, n-6) 花生四烯酸 N-(羟乙基)酰胺 Arachidonoyl ethanolamide N-(2-Hydroxyethyl)anachidonamide N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide (all-Z)- AEA |
| MDL Number | MFCD00153766 |
| PubChem Substance ID | 24890438 |
| CAS Number | 94421-68-8 |
| EC Number | 200-578-6 |
| Chemical Name Translation | 花生四烯酰乙醇胺 |
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分类
- {SNA} Cannabinoids, Core Bioreagents, Fatty Acids and conjugates, Fatty Acyls, Fatty acid amides, Lipids and Related Products, Neurobiology, Neuroscience, Pharmacologicals, Polyunsaturated, Research Essentials, Unsaturated Fatty Acids and Derivatives, 代谢组学, 代谢通路, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 脂类, 脂肪酸代谢
- {SNA} AN-AZ, Bioactive Small Molecules, Biochemicals and Reagents, Cannabinoids,
- {SA} AN-AZ, Bioactive Small Molecules, Biochemicals and Reagents, Cannabinoids, Cell Bi
相关文献及参考
- Derocq, J.M., et al., The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines,. FEBS Lett. 425 , 419-425, (1998) 摘要
- Wartmann, M., The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide,. FEBS Lett. 359 , 133, (1995)
- Szallasi, A., and Di Marzo, V., New perspectives on enigmatic vanilloid receptors. Trends Neurosci. 23 , 491-497, (2000) 摘要
- Schwarz, H., Anadamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosis. J. Neuroimmunol. 55 , 107, (1994) 摘要
- De Petrocellis, L., The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. Proc. Natl. Acad. Sci. U. S. A. 95 , 8375, (1998)
- Axelrod, J., Cannabinoid receptors and their endogenous agonist, anandamide. Neurochem. Res. 23 , 575, (1998)
- Devane, W.A., et al., Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258 , 1946, (1992) 摘要
- Twitchell, W., Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons. J. Neurophysiol. 78 , 43, (1997) 摘要
- Smart, D., et al., The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1). Br. J. Pharmacol. 129 , 227-230, (2000)
- Mackie, K., et al., Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells. Mol. Pharmacol. 44 , 498, (1993) 摘要
- Merck 14 ,624
安全信息
GHS Symbol
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE : 100 mg/kg SEX/DURATION : female 14-18 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - other postnatal measures or effects REFERENCE : PSYCDE Psychoneuroendocrinology. (Elsevier Science, 660 White Plains Road Tarrytown, NY 10591) V.1- 1975- Volume(issue)/page/year: 21,157,1996
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 140 ug/kg SEX/DURATION : female 15-21 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - stillbirth REFERENCE : NLETDU Neuroendocrinology Letters. (Brain Research Promotion, D-7400, Tubingen, Germany) V.1- 1979- Volume(issue)/page/year: 17,271,1995
