CAS 1746-01-6 MFCD00152860-2,3,7,8-Tetrachlorodibenzo-P-dioxin 硫丙磷 TAO{mole}

2,3,7,8-Tetrachlorodibenzo-P-dioxin 硫丙磷

CAS 1746-01-6 MFCD00152860

化学结构图

SMILES: Clc1cc2c(cc1Cl)Oc1cc(Cl)c(Cl)cc1O2

化学属性

Mol. Formula	C12H4Cl4O2
Mol. Weight	321.96
Flash Point	4 °C

别名和识别编码

Chemical Name	Dibenzo-p-dioxin, 2,3,7,8-tetrachloro-
CAS Number	1746-01-6
Synonym	2 2,3,6,7-Tetrachlorodibenzo-p-dioxin 2,3,6,7-四氯二苯并二【口+咢】【口+井】 2,3,7,8-Czterochlorodwubenzo-p-dwuoksyny 2,3,7,8-TCDD 2,3,7,8-TETRACHLORODIBENZO-P-DIOXANE 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN 2,3,7,8-Tetrachlor-dibenzo-p-dioxin 2,3,7,8-Tetrachlordibenzo-p-dioxin 2,3,7,8-Tetrachloro dibenzo-p-dioxin 2,3,7,8-Tetrachloro-p-dioxin 2,3,7,8-Tetrachloro-dibenzo-p-dioxin 2,3,7,8-Tetrachlorodibenzo(b,e)(1,4)dioxan 2,3,7,8-Tetrachlorodibenzo-1,4-Dioxin 2,3,7,8-Tetrachlorodibenzo-1,4-dioxin 2,3,7,8-Tetrachlorodibenzo-p-dioxin 2,3,7,8-Tetrachlorodibenzo-p-dioxin 2,3,7,8-Tetrachlorodibenzo[1,4 2,3,7,8-Tetrachlorodibenzo[b,e][1,4]dioxin 2,3,7,8-Tetrachlorodibenzodioxin
MDL Number	MFCD00152860
Chemical Name Translation	硫丙磷
EC Number	217-122-7
Wiswesser Line Notation	T C666 BO IOJ EG FG LG MG
Beilstein Registry Number	0271116
PubChem Substance ID	15625
InChI	InChI=1S/C12H4Cl4O2/c13-5-1-9-10(2-6(5)14)18-12-4-8(16)7(15)3-11(12)17-9/h1-4H

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

分类

2000/60/EC, 500 Series Drinking Water Methods, 600 Series Wastewater Methods, Alpha Sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Aroclors, PCBs, and Dioxins, Chromatography, Dioxins, EPA, Environmental Standards, European Community: ISO, DIN and DL 152, Method 513, Method 613, Method Specific, T, T-Z, TA - TE, Volatiles/ Semivolatiles
{uni_hamburg} no charge; oxygen heterocycle; carbocycle; aromatic; large ring; fused rings; 6ring; 10ring; 14ring; ether; 1fragment

产品应用

A toxic polychlorinated dibenzo-p-dioxin detected in domestic meat and poultry.

安全信息

Hazard statements

H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H300 Fatal if swallowed 吞食致命
H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。

Hazard Codes F,Xn

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P233 Keep container tightly closed. ?保持容器密闭。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
P242 Use only non-sparking tools. 只能使用无火花工具。
P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P310
P301+P316
P302+P350
P302+P352
P303+P361+P353
P304+P340
P305+P351+P338
P307+P311
P308+P313
P308+P316
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P316
P318
P319
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P331 Do NOT induce vomiting.. 不要催吐。
P332+P313
P332+P317
P337+P313
P337+P317
P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
P361+P364
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P370+P378
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P403+P233
P403+P235
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

WGK Germany3

Signal word Danger

Packing GroupI

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐：立即求医并出示该容器或标签；

Hazard Class6.1(a)

Risk Statements

R11 Highly flammable 非常易燃
R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
R48/20
R38 Irritating to skin 刺激皮肤
R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥

UN Number 2811

Restrict 剧毒化学品

Warnings 危化品目录(2015) 危险化学品

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 52 ug/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Endocrine - thyroid tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-209,1982

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 36 ug/kg/52W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Liver - tumors
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 278,548,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 52 ug/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Endocrine - thyroid tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-209,1982

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 137 ug/kg/65W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 36,396,1977

TYPE OF TEST            : TD - Toxic dose (other than lo

RTECSHP3500000

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 115 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   35,553,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 20 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 38,879,1982

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 80 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 20,101,1978

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 ug/kg
TOXIC EFFECTS :
   Liver - fatty liver degeneration
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ANYAA9 Annals of the New York Academy of Sciences.  (New York Academy of
   Sciences, 2 E. 63rd St., New York, NY 10021)  V.1-    1877-
   Volume(issue)/page/year: 320,204,1979

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 100 ug/kg
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   39,281,1988

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 200 nmol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 6,461,1984

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 500 ug/L
REFERENCE :
   AMBOCX Ambio.  A Journal of the Human Environment.  (Pergamon Press Inc.,
   Maxwell House, Fairview Park, Elmsford, NY 10523)  V.1-    1972-
   Volume(issue)/page/year: 1,1,1972

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 10 mg/L
REFERENCE :
   CMSHAF Chemosphere.  (Pergamon Press Inc., Maxwell House, Fairview Park,
   Elmsford, NY 10523) V.1-    1972-  Volume(issue)/page/year: 12,549,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 10 mg/L
REFERENCE :
   CMSHAF Chemosphere.  (Pergamon Press Inc., Maxwell House, Fairview Park,
   Elmsford, NY 10523) V.1-    1972-  Volume(issue)/page/year: 12,549,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2 mg/L
REFERENCE :
   AMBOCX Ambio.  A Journal of the Human Environment.  (Pergamon Press Inc.,
   Maxwell House, Fairview Park, Elmsford, NY 10523)  V

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1 ug/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   ENVRAL Environmental Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-    1967-  Volume(issue)/page/year: 27,74,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1500 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   ATSUDG Archives of Toxicology, Supplement.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  No.1-    1978-
   Volume(issue)/page/year: 11,344,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1250 ng/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 9,405,1971

{hazard_com

其他信息

MOL 文件:1746-01-6.mol
注意事项:此药为中等毒，施药时应注意安全防护
急救治疗:[1]用阿托品1～5mg皮下或静脉注射(按中毒轻重而定) [2]用解磷定0.4－1.2g 静脉注射(按中毒轻重而定) [3]禁用吗啡、茶硷、吩噻嗪、利血平。 [4]误服立即引吐、洗胃、导泻(清醒时才能引吐)。
Sigma Aldrich:1746-01-6(sigmaaldrich)
中毒症状:急性中毒多在12小时内发病，口服立即发病。轻度：头痛、头昏、恶心、呕吐、多汗、无力、胸闷、视力模糊、胃口不佳等，全血胆碱酯酶活力一般降至正常值的70－50%。中度：除上述症状外还出现轻度呼吸困难、肌肉震颤、瞳孔缩小、精神恍惚、行走不稳、大汗、流涎、腹疼、腹泻。重者还会出现昏迷、抽搐、呼吸困难、口吐白沫、大小便失禁，惊厥，呼吸麻痹。