CAS 64490-92-2 MFCD00150761-1H-Pyrrole-2-acetic acid,1-methyl-5-(4-methylbenzoyl)-, sodium salt, dihydrate TAO{mole}

1H-Pyrrole-2-acetic acid,1-methyl-5-(4-methylbenzoyl)-, sodium salt, dihydrate

CAS 64490-92-2 MFCD00150761

化学结构图

SMILES: O.O.[Na+].CC1C=CC(=CC=1)C(=O)C1=CC=C(CC([O-])=O)N1C

化学属性

Mol. Formula	C15H18NNaO5
Mol. Weight	315
TSCA	No

别名和识别编码

Chemical Name	Tolmetin sodium salt dihydrate
CAS Number	64490-92-2
Synonym	Sodium tolmetin dihydrate 1-Methyl-5-(p-toluoyl)pyrrole-2-acetic acid sodium salt dihydrate 5-[(p-Tolyl)carbonyl]-1-methylpyrrole-2-acetic Acid Sodium Dihydrate Tolmetin sodium salt dihydrate 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic Acid Sodium Dihydrate Tolmetin sodium dihydrate Tolumetin sodium dihydrate Sodium 1-methyl-5-p-toluoylpyrrole-2-acetate dihydrate 1-Methyl-5-p-toluoylpyrrole-2-acetic Acid Sodium Dihydrate
MDL Number	MFCD00079607
PubChem Substance ID	24900403
EC Number	252-687-3
Merck Number	14,9518
Wiswesser Line Notation	T5NJ A1 BVR D1& E1VO &-NA- &QH 2
Chemical Name Translation

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

分类

Aromatics
Heterocycles
Pharmaceuticals
Intermediates & Fine Chemicals
{SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Drug Efflux Pumps, Drug Transport Compounds, Drug Transport Proteins & Reagents, Johnson & Johnson, Membrane Protein Biology Tools, Modulators for MRP Transporters, Multi-Drug Resistance, Multi-Drug Resistance and Drug Metabolism, Proteins and Derivatives, T

产品应用

Anti-inflammatory.

安全信息

WGK Germany3

GHS Symbol

Signal word Warning

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H302 Harmful if swallowed 吞食有害

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Hazard Codes Xn

Risk Statements

R38 Irritating to skin 刺激皮肤
R22 Harmful if swallowed 吞咽有害

RTECSUX9280000

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >724 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from stomach
   Blood - changes in spleen
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 11,1099,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >622 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from large intestine
   Blood - changes in spleen
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 11,1099,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 550 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPXXDW European Patent Application. (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #134763

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1050 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 163 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 8,158,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1300 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 8,158,1977