Alpha-Methyldopa Sesquihydrate L-甲基多巴
CAS 41372-08-1 MFCD00149280
化学结构图
SMILES: O.O.O.C[C@](N)(Cc1cc(O)c(O)cc1)C(O)=O.C[C@](N)(Cc1cc(O)c(O)cc1)C(O)=O
化学属性
| Mol. Formula | (HO)2C6H3CH2C(CH3)(NH2)CO2H |
|---|---|
| Mol. Weight | 238 |
| Melting Point | >;300 °C(lit.) |
| TSCA | No |
别名和识别编码
| Chemical Name | Alpha-Methyldopa Sesquihydrate |
|---|---|
| MDL Number | MFCD00149280 |
| Synonym | Methyl dopa sesquihydrate (-)-3-(3,4-二羟基苯基)-2-甲基-L-丙氨酸 倍半水合物 α-甲基-L-多巴 L-α-甲基多巴 alpha-Methyldopa Hyperpax alpha-Methyl-L-DOPA |
| EC Number | 209-089-2 |
| CAS Number | 41372-08-1 |
| Merck Number | 14,6055 |
| InChIKey | YKFCISHFRZHKHY-NGQGLHOPSA-N |
| Chemical Name Translation | L-甲基多巴 |
| PubChem Substance ID | 24888444 |
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分类
- {SNA} Alanine Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Unnatural Amino Acids & Derivatives
相关文献及参考
- [2]. Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78(3):342-350.
- [1]. Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6(5 Pt 2):II51-II56.
- [1]. Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6(5 Pt 2):II51-II56.
- [2]. Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78(3):342-350.
安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 604 gm/kg/2Y-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 2980 mg/kg SEX/DURATION : male 65 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - other effects on male Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989
