Tumor Necrosis Factor-α human 重组肿瘤坏死因子
CAS 94948-59-1 MFCD00148692
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别名和识别编码
| Synonym | Recombinant human tumor necrosis factor alpha TNF-α TNF-α hTNF-α TNF-alpha TNF-α TNF-α hTNF-α Tumor necrosis factor-alpha hTNF-α hTNF-α |
|---|---|
| MDL Number | MFCD00148692 |
| CAS Number | 94948-59-1 |
| Chemical Name Translation | 重组肿瘤坏死因子 |
| Chemical Name | Tumor Necrosis Factor-α human |
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分类
- Cancer Research, Cell Biology,
- {SNA} Growth Factors and Cytokines, HumanKine Growth Factors and Cytokines, 细胞培养, 试剂和添加剂
- {SNA} Growth Factors and Cytokines, HumanKine Growth Factors and Cytokines, Tumor Necrosis Factor (TNF) Superfamily, 细胞培养, 试剂和添加剂
- {S
- {SNA} Core Bioreagents, Cytokines Growth Factors and Hormones (Obesity), Cytokines and Growth Factors,
相关文献及参考
- Woodward, J.K.L., et al., Stimulation and Inhibition of Uveal Melanoma Invasion by HGF, GRO, IL-1{alpha} and TGF-{beta} Invest. Ophthalmol. Vis. Sci. 43 , 3144-52, (2002) 摘要
- Zhang, C., et al., TNF-{alpha} Suppresses Prolyl-4-Hydroxylase {alpha}1 Expression via the ASK1-JNK-NonO Pathway Arterioscler. Thromb. Vasc. Biol. 27 , 1760-7, (2007) 摘要
- Zhang, J., et al., S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF- Signaling through IKK2 J. Biol. Chem. 283 , 35375-82, (2008) 摘要
- Ware, C., et al., Thomson, A.W., ed., Tumor necrosis factor-related ligands and receptors. The Cytokine Handbook 3rd ed., San Diego, CA , (1998), 549
- Aggarwal, B., and Reddy, S., Nicola, N., ed., Tumor necrosis factor (TNF). Guidebook to Cytokines and Their Receptors New York , (1994), 103-104
- Callard, R., and Gearing, A. The Cytokine Facts Book New York , (1994)
- Beutler, B., Sporn, M., and Roberts, A, ed., Cachectin/tumor necrosis factor and lymphotoxin. Peptide Growth Factors and their Receptors II New York , (1991), 39-70
- Clemens, M. J., et al. Lymphokines and Interferons, A Practical Approach , (1994), 121
安全信息
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 99,499,1990
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 10 ku/L REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1355,1991
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 100 ug/kg SEX/DURATION : female 12 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925- Volume(issue)/page/year: 135,239,1989
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE : 1 ku/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 89,447,1990
