(R)-2-(2-((R)-1-(4-Chlorophenyl)-1-Phenylethoxy)Ethyl)-1-Methylpyrrolidine Fumarate (R)-2-(2-((R)-1-(4-氯苯基)-1-苯乙氧基)乙基)-1-甲基吡咯烷富马酸盐
CAS 14976-57-9 MFCD00137486
化学结构图
SMILES: CN1CCC[C@@H]1CCO[C@](C)(C1C=CC=CC=1)C1C=CC(Cl)=CC=1.OC(=O)/C=C/C(O)=O
化学属性
| Mol. Formula | C21H26ClNO · C4H4O4 |
|---|---|
| Mol. Weight | 459.96 |
别名和识别编码
| Chemical Name | (R)-2-(2-((R)-1-(4-Chlorophenyl)-1-Phenylethoxy)Ethyl)-1-Methylpyrrolidine Fumarate |
|---|---|
| CAS Number | 14976-57-9 |
| Synonym | Aloginan fuluminol ######## (+)-2-(2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrroli lacretin Anhistan CLEMASTINE FUMARATE (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine but-2-enedioic acid agasten anhistan (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt Meclastine fumarate salt Mecloprodine Agasten aloginan clemastinehydrogenfumarate (+)-2-(2-((p-Chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methyl 1-methyl-2-(2-(methyl-p-chlorodiphenylmethyloxy)ethyl)pyrrolidine Clemastine fumarate salt (+)-2-(2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrro (2R)-2-[2-[(1R)-1-(4-CHLOROPHENYLETHOXY)]ETHYL]-1-METHYL-2-PYRROLIDINE FUMARATE (+)-lfumarate(1:1) kinotomin Alphamin lecasol CLEMASTINE FUMARATE SALT inbestan alphamin clemanil 2-(2-(1-(4-chlorophenyl)-1-phenylethoxy)ethyl)-1-methylpyrrolidine hs592 |
| MDL Number | MFCD00137486 |
| PubChem Substance ID | 24278344 |
| EC Number | 239-055-2 |
| Chemical Name Translation | (R)-2-(2-((R)-1-(4-氯苯基)-1-苯乙氧基)乙基)-1-甲基吡咯烷富马酸盐 |
| Wiswesser Line Notation | T5NTJ A1 B2OX1&R&R DG &QV1U1VQ -T |
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现货库存
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分类
- {SNA} Antagonists, Bioactive Small Molecule Alphabetical Index, CI-CZ, Histaminergics, Neuroscience, Neurotransmission, Neurotransmitters, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Chiral Reagents
- Heterocycles
- {SNA} Antagonists, Cell Biology, Cell Signaling and Neuroscience, Histaminergics, Neuroscience, Neurotransmission, Neurotransmitters, New Products
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Aromatics
产品应用
- H1 Histamine receptor antagonist. Antihistaminic.
相关文献及参考
- [2]. Schran, H.F., et al., The pharmacokinetics and bioavailability of clemastine and phenylpropanolamine in single-component and combination formulations. J Clin Pharmacol, 1996. 36(10): p. 911-22.
- Weidmann, et al.: Boll. Chim. Farm., 106, 467 (1967),
- [1]. Seifert, R., et al., Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue. Mol Pharmacol, 1992. 42(2): p. 227-34.
- [1]. Seifert, R., et al., Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue. Mol Pharmacol, 1992. 42(2): p. 227-34.
- [2]. Schran, H.F., et al., The pharmacokinetics and bioavailability of clemastine and phenylpropanolamine in single-component and combination formulations. J Clin Pharmacol, 1996. 36(10): p. 911-22.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 730 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - changes in motor activity (specific assay) REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 106,467,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 175 mg/kg TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Behavioral - muscle contraction or spasticity Gastrointestinal - nausea or vomiting REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 106,467,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,230,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >50 mg/kg TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Behavioral - muscle contraction or spasticity Gastrointestinal - nausea or vomiting REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(i
GHS Symbol
