ANTIPAIN DIHYDROCHLORIDE
CAS 37682-72-7 MFCD00135957
化学结构图
SMILES: Cl.Cl.CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)NC(CC1=CC=CC=C1)C(O)=O)C(=O)NC(CCCNC(N)=N)C=O
化学属性
| Mol. Formula | C27H44N10O6· 2 HCl |
|---|---|
| Mol. Weight | 678 |
别名和识别编码
| Chemical Name | Antipain dihydrochloride from microbial source |
|---|---|
| Synonym | N-(Nα-Carbonyl-Arg-Val-Arg-al)-Phe N-(Nα-Carbonyl-Arg-Val-Arg-al)-Phe |
| MDL Number | MFCD00135957 |
| PubChem Substance ID | 24891067 |
| CAS Number | 37682-72-7 |
| Chemical Name Translation |
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分类
- {SNA} A to C,
- {SNA} A to C, Aldehydes, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Apoptosis Enzymes, Application Index, Broad Spectrum Inhibitors of Proteolytic Enzyme Classes, Building Blocks, C13-C60, Calpain, Calpain II, Calpain II Inhibitors,
相关文献及参考
- [2]. Suda H,et al. Antipain, a new protease inhibitor isolated from actinomycetes. J Antibiot (Tokyo). 1972 Apr;25(4):263-6.
- [3]. Sudha VT, et al. Identification of a serine protease as a major allergen (Per a 10) of Periplaneta americana. Allergy. 2008 Jun;63(6):768-76.
- [4]. Nomura T, et al. Inhibiting effects of antipain on urethane-induced lung neoplasia in mice. Br J Cancer. 1980;42(4):624‐626.
- [5]. Katz J, et al. Antipain and leupeptin restrict uterine DNA synthesis and function in mice. Proc Natl Acad Sci U S A. 1977;74(9):3754‐3757.
- , Beynon, R.J. and Bond, J.S., ed. Proteolytic Enzymes: A Practical Approach New York, NY , (1989), 242
- , Zollner, H., ed. Handbook of Enzyme Inhibitors 2nd ed.,, (1993), 94
- 1. Vaccari, M., et al., Effects of the protease inhibitor antipain on cell malignant transformation Anticancer Res. 19 , 589-596, (1999)
- Dawson, R., ed. Data for Biochemical Research 3rd ed.,, (1987), 328
- {MC
