NADPH tetrasodium salt 还原型辅酶II
CAS 2646-71-1 MFCD00036263
化学结构图
SMILES: NC(=O)C1=CN([C@@H]2O[C@H](COP(=O)([O-])OP(=O)([O-])OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](OP(=O)([O-])[O-])[C@@H]3O)[C@@H](O)[C@H]2O)C=CC1.[Na+].[Na+].[Na+].[Na+]
化学属性
| Mol. Formula | C21 H26 N7 O17 P3 . 4 Na |
|---|---|
| Mol. Weight | 833.35 |
| Density | 2.28 |
| Solubility | 易溶于水(50 mg/ml). |
| Stability | 对热和空气敏感 |
别名和识别编码
| Chemical Name | NADPH tetrasodium salt |
|---|---|
| Synonym | 2'-NADPH 2′-NADPH 水合物 Beta-NADPH Tetrasodium Salt Hydrate {} {LY} b-NADPH Tetrasodium Salt Hydrate {} {} {SNA} Triphosphopyridine nucleotide reduced 四钠盐 {} {} {} {SNA} TPNH2 Na4 {} {} {} {} {LY} NADPH (tetrasodium salt) {} {} {} {} {} {SNA} Dihydronicotinamide adenine dinucleotide phosphate 四钠盐 {} {} {} {} {} {} {SNA} Coenzyme II reduced 四钠盐 {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} |
| MDL Number | MFCD00036263 |
| PubChem Substance ID | 87576448 |
| CAS Number | 2646-71-1 |
| EC Number | 220-163-3 |
| Merck Number | 6348 |
| Beilstein Registry Number | 2384789 |
| Chemical Name Translation | 还原型辅酶II |
| InChIKey | WYWWVJHQDVCHKF-ITGWJZMWSA-J |
| LabNetwork Molecule ID | LN00196844 |
| Canonical SMILES | NC1=C2C(N([C@H]3[C@H](OP(O[Na])(O[Na])=O)[C@H](O)[C@@H](COP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H](N5C=C(C(N)=O)CC=C5)O4)(O[Na])=O)(O[Na])=O)O3)C=N2)=NC=N1 |
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分类
- {SNA} Application Index, Biochemicals and Reagents, Bulk vials, Cell Biology, Cell Signaling Enzymes, Cofactors, Core Bioreagents, Dihydrofolate reductase, Enzymes, Inhibitors, and Substrates, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Metabolomics, NAD(P)(H) and Analogs, NADPH, Nucleosides and Nucleotides, Nucleosides, Nucleotides, Oligonucleotides, Oxidation-Reduction, Research Essentials, Substrate/Cofactor, TCA
- {SNA} Biochemicals and Reagents, Bulk vials, NAD(P)(H) and Analogs, NADPH, Nucleosides, Nucleotides, Oligonucleotides
- {SNA} Bioche
产品应用
- 通常作为电子供体，是很多氧化还原酶(包括一氧化氮合成酶)的辅酶(cofactor)。
相关文献及参考
- [2]. Ng CY, F et al. Rational design of a synthetic Entner-Doudoroff pathway for improved and controllable NADPH regeneration. Metab Eng. 2015;29:86-96.
- [3]. Ju HQ, Lin JF, et al. NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications. Signal Transduct Target Ther. 2020;5(1):231. Published 2020 Oct 7.
- [4]. Stockwell BR, et al. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell. 2017;171(2):273-285.
- Beil. 26 ,IV,3672
- Brann D, Raz L, Wang R, et al., Estrogen signaling and neuroprotection in cerebral ischemia. J. Neuroendocrinol. 24(1) , 34-47, (2011)
- Canevari L, Clark JB., Alzheimer's disease and cholesterol: the fat connection. Neurochem. Res. 32 , 739-750, (2007) 摘要
- Drummond GR, Selemidis S, et al., Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat. Rev. Drug Discov. 10 , 453-471, (2011) 摘要
- Fraser PA., The
安全信息
GHS Symbol
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
