Coenzyme B12 辅酶
CAS 13870-90-1 MFCD00135609
化学结构图
SMILES: CC1(C)[C@H](CCC(N)=O)C2=NC1=CC1=NC(=C(C)C3=N[C@@](C)([C@H]4[C@H](CC(N)=O)[C@@](C)(CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@@H]5[C@@H](CO)O[C@@H]([C@@H]5O)N5C=NC6C=C(C)C(C)=CC5=6)C(=C2C)N4[Co+]C[C@H]2O[C@@H]([C@@H](O)[C@H]2O)N2C=NC4=C2N=CN=C4N)[C@@](C)(CC(N)=O)[C@@H]3CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O
化学属性
| Mol. Formula | C72H100CoN18O17P |
|---|---|
| Mol. Weight | 1580 |
别名和识别编码
| Chemical Name | Coenzyme B12 |
|---|---|
| Synonym | 5′-Deoxyadenosylcobalamine Adenosyl cobalamine Cobamamide DMBC coenzyme 5'-Deoxyadenosyl vitamin B12 5'-Deoxyadenosylcobalamin 5'-Deoxyadenosylcobalamine Adenosyl cobalamine Cobamamide DMBC coenzyme 5-Deoxyadenosylcobalamin Adenosyl cobalamine; 5'-Deoxyadenosylcobalamin Adenosylcobalamin Calomide Cobalamine coenzyme Cobamamide Coenzyme B12 DBC coenzyme Deoxyadenosylcobalamin Dibencozide Funacomide LM 176 Vitamin B12 coenzyme |
| MDL Number | MFCD00135609 |
| PubChem Substance ID | 24892282 |
| Beilstein Registry Number | 4122932 |
| CAS Number | 13870-90-1 |
| EC Number | 237-627-6 |
| Chemical Name Translation | 辅酶 |
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分类
- {SNA} Biochemicals and Reagents, Cofactors, Enzymes, Inhibitors, and Substrates, Nutrition Research, Other Cofactors, Vitamin B, Vitamin B12, Vitamins
- {SNA} Cofactors, Other Cofactors, Vitamin B, Vitamin B12, Vitamins, 生化试剂, 酶、抑制剂和底物
- {SNA} Cofactors, Other Cofactors, Vitamin B, Vitamin B12, Vitamins, 生化试剂, 细胞生物学, 营养研究, 酶、抑制剂和底物
相关文献及参考
- [2]. Marsh EN, et al. Adenosylcobalamin enzymes: Theory and experiment begin to converge. Biochim Biophys Acta. 2012 Nov;1824(11):1154-64.
- Banerjee R., B12 trafficking in mammals: A for coenzyme escort service. ACS Chem. Biol. 1 , 149-159, (2006) 摘要
- Gruber K, Puffer B, Kräutler B., Vitamin B12-derivatives-enzyme cofactors and ligands of proteins and nucleic acids. Chem. Soc. Rev. 40 , 4346-4363, (2011) 摘要
- Hannibal L, Kim J, Brasch NE, Wang S, et al., Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product. Mol. Genet. Metab. 97 , 260-266, (2009) 摘要
- Kim J, Hannibal L, Gherasim C, et al., A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins. J. Biol. Chem. 284 , 33418-33424, (2009) 摘要
- Koutmos M, Gherasim C, Smith JL, Banerjee R., Structural basis of multifunctionality in a vitamin B12-processing enzyme. J. Biol. Chem. 286 , 29780-29787, (201
安全信息
- S22 Do not breathe dust 不要吸入粉尘；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethi
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405
