CAS 476-70-0 MFCD00135040-Boldine 波尔定碱 TAO{mole}

Boldine 波尔定碱

CAS 476-70-0 MFCD00135040

化学结构图

SMILES: COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C

化学属性

Mol. Formula	C19 H21 N O4
Mol. Weight	327.37
Melting Point	162-164 ºC

别名和识别编码

Chemical Name	Boldine
MDL Number	MFCD00135040
CAS Number	476-70-0
Synonym	(+)-(S)-Boldine (+)-(s)-boldine (+)-BOLDINE (+)-Boldine (-)-6-Methyl-1,10-dimethoxy-5,6,6aα,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol (6aS)-5,6,6a,7-Tetrahydro-1,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,9-diol (S)-Boldine (s)-boldine (s)-yl 1,10-DIMETHOXY-2,9-DIHYDROXYAPORPHINE 1,10-dimethoxy-6a-alpha-aporphine-2,9-diol 1,10-dimethoxy-6a-alpha-aporphine-9-diol 2 6-DIHYDROXY-3 5-DIMETHOXYAPORPHIN 2,9-DIHYDROXY-1,10-DIMETHOXYAPORPHINE 2,9-Dihydroxy-1,10-dimethoxyaporphine 2,9-Dihydroxy-1,10-dimethoxyaporphine, Boldine 2,9-二羟基-1,10-二甲氧基阿朴啡 4H-Dibenzo(de,g)quinoline-2,9-diol, 4h-dibenzo(de,g)quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-meth 4h-dibenzo[de,g]quinoline-2,9
Beilstein Registry Number	0094036
EC Number	207-509-9
PubChem Substance ID	10154
Chemical Name Translation	波尔定碱
Merck Number	13,1316
Wiswesser Line Notation	T C6666 1A Q KN&TT&J EO1 FQ K1 PQ QO1
InChI	InChI=1S/C19H21NO4/c1-20-5-4-10-7-15(22)19(24-3)18-12-9-16(23-2)14(21)8-11(12)6-13(20)17(10)18/h7-9,13,21-22H,4-6H2,1-3H3/t13-/m0/s1

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分类

{SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, B, BI - BZ, Biochemicals and Reagents, Chromatography, Drugs & Metabolites, Enzyme Inhibitors, Enzymes, Inhibitors, and Substrates, Forensic and Veterinary Standards, Neat Compounds, Protease Inhibitor Specificity Index, Protease Inhibitors, Trypsin
{SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, B, BI - BZ, Biochemicals and Reagents, Chromatography, Drugs & Metabolites, Enzyme Inhibitors, Fo

安全信息

GHS Symbol

RTECSCE0750000

Hazard statements

H302 Harmful if swallowed 吞食有害

WGK Germany3

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes Xn

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害

Packing GroupIII

Safety Statements

S1 Keep locked up 上锁；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S20 When using do not eat or drink 使用时，不得进食，饮水；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Hazard Class6.1(b)

UN Number 1544

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 145 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4185119

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Cardiac - change in rate
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 38,537,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Cardiac - change in rate
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 38,537,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 50 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 260,145,1991

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 100 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 260,145,1991

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P301+P317
P330 Rinse mouth. 漱口
P501 Dispose of contents/container to..… 处理内容物/容器.....

Storage condition -20°C -20℃

其他信息

Sigma Aldrich:476-70-0(sigmaaldrich)
MOL 文件:476-70-0.mol