CAS 65-28-1 MFCD00134201-2-[[N-(m-Hydroxyphenyl)-p-toluidino]methyl]-2-imidazoline mesylate 2-[N-(间羟基)-对甲苯胺甲基]-2-咪唑啉甲磺酸盐 TAO{mole}

2-[[N-(m-Hydroxyphenyl)-p-toluidino]methyl]-2-imidazoline mesylate 2-[N-(间羟基)-对甲苯胺甲基]-2-咪唑啉甲磺酸盐

CAS 65-28-1 MFCD00134201

化学结构图

SMILES: CS(=O)(=O)O.Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1

化学属性

Mol. Formula	C17H19N3O.CH4O3S
Mol. Weight	377.46
Melting Point	180-182
Solubility	ethanol: soluble26 mg/mL H2O: soluble50 mg/mL
Appearance	powder

别名和识别编码

Chemical Name	2-[[N-(m-Hydroxyphenyl)-p-toluidino]methyl]-2-imidazoline mesylate
CAS Number	65-28-1
Synonym	瑞支亭 PHENTOLAMINE MESILATE 酚妥拉明甲磺酸盐 regitinmethanesulphonate Phentolamine mesylate VASOMAX REGITIN Regitine methanesulfonate Phentolamine methanesulfonate salt; 3-[N-(2-Imidazolin-2-ylmethyl)-p-toluidino]phenol methanesulphonate 2-(N-[M-HYDROXYPHENYL]-P-TOLUIDINOMETHYL)IMIDAZOLINE METHANESULFONATE SALT phentolaminemethanesulphonate PHENTOLAMINE MESYLATE 2-[N-(间羟基)-对甲苯胺甲基]-2-咪唑啉甲磺酸盐酚胺唑啉马来酸盐
MDL Number	MFCD00134201
PubChem Substance ID	135727347
EC Number	200-604-6
Chemical Name Translation	2-[N-(间羟基)-对甲苯胺甲基]-2-咪唑啉甲磺酸盐
Merck Number	7264
Reaxys-RN	3826682
Beilstein Registry Number	3826682
Wiswesser Line Notation	T5M CN BUTJ B1NR CQ&R D1 &WSQ1
LabNetwork Molecule ID	LN00195558

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分类

{SNA} Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Signal
{SNA} Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Fluorination Ready Pharma-Developed Compounds, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Novartis, P-PH, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物

产品应用

α-肾上腺素受体拮抗剂；外周血管舒张剂。

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P304+P340+P312
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P332+P313
P302+P352+P312+P362+P364
P501 Dispose of contents/container to..… 处理内容物/容器.....
P305+P351+P338+

Signal word

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H335 May cause respiratory irritation 可能导致呼吸道刺激
H319 Causes serious eye irritation 严重刺激眼睛
H302+H312+H332
H332 Harmful if inhaled 吸入有害
H302 Harmful if swallowed 吞食有害
H312 Harmful in contact with skin 皮肤接触有害

RTECSSL5430000

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xn Xn,Xi

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

UN Number 3249

Storage condition 储存温度2-8℃

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,667,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JNPHAG Journal de Pharmacologie.  (SPPIF, B.P.22, F-41353 Vineuil, France)
   V.1-    1970-  Volume(issue)/page/year: 5,101,1974

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,667,1982

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 275 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,667,1982

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Jap

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4 mg/kg
SEX/DURATION            : female 22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 76,415,1986

其他信息

RTECS号:SL5430000
MOL 文件:65-28-1.mol
用途:主要用于心血管系统疾病、以及糖尿病、肾病、中毒性肠麻痹、急性呼吸窘迫综合症、毛细支气管炎、重症哮喘等。
color:white to off-white
PackingGroup:III
HazardClass:6.1(b)