Gonadorelin Acetate 醋酸戈那瑞林
CAS 71447-49-9 MFCD00133489
化学结构图
SMILES: CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CNC2C=CC=CC1=2)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O.CC(O)=O.CC(O)=O
化学属性
| Mol. Formula | C55H75N17O13.2C2H4O2 |
|---|---|
| Mol. Weight | 1302.59 |
别名和识别编码
| Chemical Name | Gonadorelin Acetate |
|---|---|
| Synonym | Gonadoliberin Gonadorelin diacetate LHRH diacetate Gonadoliberin Gonadotropin releasing hormone LH-RH LH-RH Gonadotropin releasing hormone Luteinizing hormone releasing hormone human acetate salt |
| MDL Number | MFCD00133489 |
| CAS Number | 71447-49-9 |
| EC Number | 232-895-0 |
| Chemical Name Translation | 醋酸戈那瑞林 |
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分类
- Androgen Modulators, Antitumor Agents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, LH-RH, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Releasing Factors, Therapy Adjuncts, Tumor Growth Regulation
- {SNA} Androgen Modulators, LH-RH, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Releasing Factors, Therapy Adjuncts, 抗肿瘤药物, 癌症研究, 细胞信号转导和神经科学, 细胞生物学, 肿瘤生长调节
- {SNA} Androgen Modulators, Antitumor Agents, Cancer Research,
相关文献及参考
- Imai, A., and Tamaya, T., GnRH receptor and apoptotic signaling. Vitam. Horm. 59 , 1-33, (2000) 摘要
- Ortmann, O., and Diedrich, K., Pituitary and extrapituitary actions of gonadotrophin-releasing hormone and its analogues. Hum. Reprod. 14 , 194-206, (1999) 摘要
- Shacham, S., et al., Mechanism of GnRH receptor signaling: from the membrane to the nucleus. Ann. Endocrinol. 60 , 79-88, (1999)
- Manikkam, M., et al., Developmental programming: impact of prenatal testosterone excess on pre- and postnatal gonadotropin regulation in sheep. Biogerontology 78 , 648-60, (2008)
安全信息
GHS Symbol
- P308+P313
- P201 Obtain special instructions before use. 使用前获取专门指示。
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- R60 May impair fertility 可能降低生殖能力
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 416 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,474,1995
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,474,1995
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 154 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo J
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,273,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 5400 ug/kg
SEX/DURATION : female 17-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Maternal Effects - uterus, cervix, vagina
Reproductive - Maternal Effects - parturition
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 20,8871,1986TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 54 mg/kg
SEX/DURATION : female 17-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on NewbornTYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 540 ug/kg
SEX/DURATION : female 17-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 20,8871,1986TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE
