1-Ethyl-6-Fluoro-4-Oxo-7-(Piperazin-1-Yl)-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic Acid 1-乙基-6-氟-1,4-二氢-4-氧代-7-(-哌嗪基)-1,8-萘啶-3-羧酸
CAS 74011-58-8 MFCD00133308
化学结构图
SMILES: CCN1C=C(C(O)=O)C(=O)C2C=C(F)C(=NC1=2)N1CCNCC1
化学属性
| Mol. Formula | C15H17FN4O3 |
|---|---|
| Mol. Weight | 320.36 |
| Melting Point | 220-224 |
别名和识别编码
| Chemical Name | 1-Ethyl-6-Fluoro-4-Oxo-7-(Piperazin-1-Yl)-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic Acid |
|---|---|
| CAS Number | 74011-58-8 |
| Synonym | Flumark Enofloxacin 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic Acid CI 919 Bactidan Enoksetin Comprecin AT-2266 PD 107779 Penetrex 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid NSC 629661 1-乙基-6-氟-1,4-二氢-4-氧代-7-(1-哌嗪基)-1,8-萘啶-3-羧酸 Enoxacin 依诺沙星 Enoram Enofloxacine |
| MDL Number | |
| PubChem Substance ID | 87560179 |
| InChIKey | IDYZIJYBMGIQMJ-UHFFFAOYSA-N |
| Chemical Name Translation | 1-乙基-6-氟-1,4-二氢-4-氧代-7-(-哌嗪基)-1,8-萘啶-3-羧酸 |
| Reaxys-RN | 3628995 |
| Merck Number | 3587 |
| Wiswesser Line Notation | T66 BV EN GNJ CVQ E2 IF H- DT6M DNTJ |
| Beilstein Registry Number | 3628995 |
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分类
- A - K, ABC Transporter Research, Alphabetic, Analytical Standards, Analytical/Chromatography, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Chemical Structure, Chemical Structure Class, Chromatography, Drugs & Metabolites, Drugs of Abuse, E, EA - EO, Enzymes, Inhibitors, and Substrates, Forensic and Veterinary Standards, Inhibitors,
- {SNA} Alphabetical Index
产品应用
- A flurorquinolone antibacterial used to treat urinary tract infections and gonorrhea.
相关文献及参考
- Liu, A., et al.: Antimicrob. Agents Chemother., 54, 1393 (2010),
- Chen, P., et al.: Drug Test Anal., 2, 24 (2010),
- Gohil, V., et al.: Nat., Biotechnol., 28, 249 (2010),
- Yoshida, H., et al. J. Bacteriol. 172 , 6942-6949, (1990)
- Merck 14 ,3587
安全信息
GHS Symbol
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >1600 mg/kg TOXIC EFFECTS : Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 3),192,1984
{hTYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : >1600 mg/kg TOXIC EFFECTS : Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 3),192,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 327 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 3),192,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Skin and Appendages - hair REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8
TYPE OF TEST : LD50 - Lethal dos
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 200 ng/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 281,207,1992
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 11 gm/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 3),301,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 91 gm/kg SEX/DURATION : male 13 week(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 3),293,1984
